InventoryRef 4043802/03/2011
METHYL ACETOACETATE
Methyl acetoacetate
METHYL ACETOACETATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 105-45-3PubChem CID 7757
Methyl acetoacetate
Methyl acetoacetate appears as a clear colorless liquid. Flash point 158 °F. Denser than water and slightly soluble in water. Vapors heavier than air. — CAMEO Chemicals
- IUPAC name
- methyl 3-oxobutanoate
- Molecular formula
- C5H8O3
- Molecular weight
- 116.11 g/mol
- Exact mass
- 116.047344113 Da
- XLogP3
- 0.0
- Topological polar surface area
- 43.4 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
MethylacetoacetateMethyl acetylacetateAcetoacetic acid methyl esterMethyl 3-oxobutyrate3-Oxobutanoic acid methyl esterMethyl acetylacetonateButanoic acid, 3-oxo-, methyl esterAcetoacetic methyl ester
16 more reported names
1-Methoxybutane-1,3-dioneAcetoacetic acid, methyl esterMethylester kyseliny acetoctoveCW4I82QAX1RefChem:817587203-299-8Methylacetoacetic acid3-Oxobutyric Acid Methyl Ester3-oxo-butyric acid methyl ester3-oxo-Butanoic acid methyl esterAcetoacetate methyl estermethyl acetoacetate(MAA)METHYL ACETOACETATE [MI]Tox21_200162s3091CAS-105-45-3
External database identifiers
- ChEBI:CHEBI:166454
- ChEMBL:CHEMBL3186053
- EPA DTXSID:DTXSID9026716
- PubMed:22852822
- PubMed:22841059
- PubMed:22649326
- PubMed:22506389
- PubMed:22454614
- PubMed:22414680
- PubMed:22412624
- PubMed:22065500
- PubMed:22064645
- PubMed:22002070
- PubMed:21839549
- PubMed:21754804
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:166454
Methylacetoacetic acid
- Formula
- C5H8O3
- Average mass
- 116.116 g/mol
- Monoisotopic mass
- 116.04734 Da
- Formal charge
- 0
- oxo carboxylic acid — is a (CHEBI:25754)
- oxo carboxylic acid — is a (CHEBI:25754)
Additional curated names
methyl 3-oxobutanoate
Cross-references from this source
- CAS: 105-45-3 — ChemIDplus
- MANUAL_X_REF: 13874867 — ChemSpider
- MANUAL_X_REF: C02233 — KEGG COMPOUND
- MANUAL_X_REF: HMDB0000310 — HMDB
- MANUAL_X_REF: LMFA01060005 — LIPID MAPS
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7757
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 536 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 536 °F (280 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 280 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 336 to 338 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 171.7 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 169.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 171.7 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.076 (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.0762 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Bulk density: 9 lb/gal at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 1.08 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 158 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 170 °F (77 °C) (open cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 77 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: log Kow = -0.69 /Estimated/ Source: Hazardous Substances Data Bank (HSDB)
- LogP: -0.26 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -112 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: -80 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -80 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -27 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Odor: Agreeable odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Methyl acetoacetate appears as a clear colorless liquid. Flash point 158 °F. Denser than water and slightly soluble in water. Vapors heavier than air. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Refractive Index: Index of refraction: 1.4184 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in 2 parts water; miscible with alcohol and ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOLUBILITY IN WATER: 38 G/100 ML Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 500.0 mg/mL Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml: 50 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 0.89 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 0.892 mm Hg at 25 °C /Extrapolated/ Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.17 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Viscosity: 1.704 cPa at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: INHALATION: Call for medical aid. Remove to fresh air. If not breathing, give aritificial respiration. If breathing is difficult, give oxygen.; EYES: Flush eyes with copious amounts of water for at least 15 minutes.; SKIN: Wash with soap and copious amounts of water. (USCG, 1999) Source: CAMEO Chemicals
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for 0.6% (12 of 1934) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H319 (95.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1934 reports by companies from 8 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 12 of 1934 reports by companies.; There are 7 notifications provided by 1922 of 1934 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- Precautionary Statement Codes: P210, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 3.1 was calculated for methyl acetatoactate(SRC), using an estimated log Kow of -0.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.0(SRC), determined from a structure estimation method(2), indicates that methyl acetoacetate is expected to have very high mobility in soil(SRC). Volatilization of methyl acetoacetate from moist soil surfaces is expected to be slow(SRC) given an estimated Henry's Law constant of 2.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure of 0.892 mm Hg(3), and water solubility, 5X10+5 mg/L(4). A base-catalyzed second-order hydrolysis rate constant of 0.57 L/mole-sec(SRC) was estimated using a structure estimation method(5); this corresponds to half-lives of 140 and 14 days at pH values of 7 and 8, respectively(5). Methyl acetoacetate would be expected to hydrolyze in moist soil under basic conditions(SRC). Methyl acetoacetate is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.892 mm Hg(3). One screening test observed 78% biodegradation of methyl acetoacetate in 14 days(6); although this study was not specific to soil, it suggests that biodegradation in soil may be rapid(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.0(SRC), determined from a structure estimation method(2), indicates that methyl acetoacetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected to be slow(3) based upon an estimated Henry's Law constant of 2.7X10-7 atm-cu m/mole(SRC), derived from its vapor pressure of 0.892 mm Hg(4), and water solubility, 5X10+5 mg/L(5). A base-catalyzed second-order hydrolysis rate constant of 0.57 L/mole-sec(SRC) was estimated using a structure estimation method(6); this corresponds to half-lives of 140 and 14 days at pH values of 7 and 8, respectively(6). According to a classification scheme(7), an estimated BCF of 3.1(SRC), from an estimated log Kow of -0.69(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl acetoacetate, which has a vapor pressure of 0.892 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase methyl acetoacetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 days(SRC), calculated from its rate constant of 3.25X10-13 cu cm/molecule-sec at 25 °C(3). Methyl acetoacetate does not absorb light with wavelengths >290 nm(4) and is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Insulators; Intermediate; Cleaning agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Intermediate Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used for organic synthesis and as solvent for cellulose ethers; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Solvent for cellulose ethers; component of solvent mixtures for cellulose esters; chemical intermediate for org compounds. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used in synthesis of nifedipine. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Principal Uses: herbicides, pesticides, chemical synthesis, protection of NH2 groups. /From table/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Principal outlets for MAA are the manufacture of the organophosphorus insecticide diazinon and the uracil herbicides bromacil and terbacil. Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... Amine protecting agent in the manufacture of antibiotics and synthetic sweeteners. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for METHYL ACETOACETATE
INCI name
METHYL ACETOACETATE
Description
Methyl acetoacetate
Record provenance
- Inventory reference
- 40438
- Imported identity
- METHYL ACETOACETATE
- Source update
- 02/03/2011
Annex records for METHYL ACETOACETATE
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How METHYL ACETOACETATE appears in the CosIng inventory
The CosIng inventory lists METHYL ACETOACETATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
METHYL ACETOACETATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
METHYL ACETOACETATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, METHYL ACETOACETATE carries the following function designation(s):
CAS 105-45-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for METHYL ACETOACETATE
This page reproduces the CosIng inventory entry for METHYL ACETOACETATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research METHYL ACETOACETATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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