Is ISOCINEOLE safe to use in EU cosmetics?

ISOCINEOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 470-67-7?

CAS 470-67-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4035802/03/2011

ISOCINEOLE

1-Methyl-4-(1-methylethyl)-7-oxabicyclo[2.2.1]heptane; 1,4-Cineol; Isoeucalyptol; 1,6-Epoxy-p-menthane

ISOCINEOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 470-67-7

CAS 470-67-7PubChem CID 10106

1,4-Cineole

1,4-cineole is an oxabicycloalkane consisting of p-menthane with an epoxy bridge across positions 1 and 4. It has a role as a central nervous system depressant, a fumigant insecticide and a plant metabolite. It is a cineole and an oxabicycloalkane. — ChEBI

IUPAC name: 1-methyl-4-propan-2-yl-7-oxabicyclo[2.2.1]heptane

Molecular formula: C10H18O
Molecular weight: 154.25 g/mol
Exact mass: 154.135765193 Da
XLogP3: 2.5
Topological polar surface area: 9.2 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

Isocineole1,4-Cineol1,4-EPOXY-P-MENTHANE1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptanep-Menthane, 1,4-epoxy-FEMA No. 3658Isocineplep-Menthane, 1,4-epoxy

16 more reported names

1-Isopropyl-4-methyl-7-oxabicyclo(2.2.1)heptane1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane1-Methyl-4-(1-methylethyl)-7-oxabicyclo(2.2.1)heptane7-Oxabicyclo(2.2.1)heptane, 1-isopropyl-4-methyl-B55JTU839B7-Oxabicyclo(2.2.1)heptane, 1-methyl-4-(1-methylethyl)-7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-4-isopropyl-1-methyl-7-oxabicyclo[2.2.1]heptaneCineole EP Impurity A1-METHYL-4-(1-METHYLETHYL)-7-OXABICYCLO[2.2.1]HEPTANE(1s,4s)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane1,4-Cineole (natural)HSDB 5425EINECS 207-428-9BRN 0104974UNII-B55JTU839B

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:80788
ChEMBL:CHEMBL2288022
EPA DTXSID:DTXSID3047396
PubMed:23449869

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ISOCINEOLE

INCI name

ISOCINEOLE

Description

1-Methyl-4-(1-methylethyl)-7-oxabicyclo[2.2.1]heptane; 1,4-Cineol; Isoeucalyptol; 1,6-Epoxy-p-menthane

Record provenance

Inventory reference: 40358
Imported identity: ISOCINEOLE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for ISOCINEOLE

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Key data

CAS

470-67-7

207-428-9

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Records sharing a CAS or EC identity

CINEOLE

Ingredients with overlapping formulation functions

ISOBUTYL-METHOXYPYRAZINEPERFUMING

ISOBUTYLQUINOLINE ISOMERSPERFUMING

ISOBUTYLTHIAZOLEPERFUMING

ISOCAMPHENYL CYCLOHEXANOL MIXED ISOMERSPERFUMING

ISOCYCLOCITRALPERFUMING

ISOCYCLOGERANIOLPERFUMING

ISODECYL ACETATEPERFUMING

ISODECYL ALCOHOLPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ISOCINEOLE appears in the CosIng inventory

The CosIng inventory lists ISOCINEOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ISOCINEOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ISOCINEOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ISOCINEOLE carries the following function designation(s):

PERFUMING

CAS 470-67-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ISOCINEOLE

This page reproduces the CosIng inventory entry for ISOCINEOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ISOCINEOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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