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InventoryRef 3991902/03/2011

4-ETHYLPHENOL

4-Ethylphenol

4-ETHYLPHENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 123-07-9
CAS 123-07-9PubChem CID 31242

4-Ethylphenol

4-ethylphenol is a member of the class of phenols carrying an ethyl substituent at position 4. It has a role as a fungal xenobiotic metabolite. — ChEBI

IUPAC name
4-ethylphenol
Molecular formula
C8H10O
Molecular weight
122.16 g/mol
Exact mass
122.073164938 Da
XLogP3
2.6
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

p-EthylphenolPhenol, 4-ethyl-Phenol, p-ethyl-1-Ethyl-4-hydroxybenzene1-Hydroxy-4-ethylbenzenepara-Ethylphenol4-HydroxyphenylethaneParaethylphenol
16 more reported names
FEMA No. 3156AGG7E6G0ZCNSC-62012CHEBI:49584RefChem:522879204-598-64-ethyl-phenolPhenol, 3(or 4)-ethyl-(4-hydroxyphenyl)ethaneBENZENE,1-ETHYL,4-HYDROXY4-HydroxyethylbenzeneHydroxyphenylethane, p-4-ethyl phenolCAS-123-07-9HSDB 5598EINECS 204-598-6
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31242

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 0.4% (7 of 1875) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H314 (86%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (81.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1875 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 7 of 1875 reports by companies.; There are 13 notifications provided by 1868 of 1875 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Health Effects: Respiratory distress, cardiovascular collapse, shock, ventricular tachycardia, and coma in an adult. Liver, lung, central nervous system and renal injury may also occur (T36). Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF value of 54 was calculated for p-ethylphenol(SRC), using a measured log Kow of 2.58(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms may be an important fate process(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 600(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), indicates that p-ethylphenol will have low mobility in soil(SRC). Based on limited data, biodegradation of this compound is likely. A system where water was passed through contaminated soil (initial p-ethylphenol concentration = 4000 ug/l) and then through an upflow aerated column was capable of 76% removal in 37 days(4). p-Ethylphenol's values for vapor pressure(5) and Henry's Law constant(5,6,SRC) indicate that volatilization from dry and moist soil surfaces is possible, but will not be a major fate process for this compound(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 600(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), indicates that p-ethylphenol may adsorb to suspended solids and sediment(SRC) in water. Based on limited soil study data, biodegradation of this compound is likely. 76% removal of p-ethylphenol in 37 days was seen in a soil column study(4). p-Ethylphenol should volatilize from water surfaces based on an estimated Henry's Law constant of 1.2X10-6 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(5) and water solubility(6). Estimated half-lives for a model river and model lake are 33 and 245 days, respectively(3,SRC). An estimated BCF value of 54(3,SRC), from an experimental log Kow(2), suggests that p-ethylphenol may bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a suggested classification scheme(1), a measured vapor pressure of 0.0372 mm Hg at 25 °C(2) indicates that p-ethylphenol will mainly exist in the vapor phase in the ambient atmosphere(SRC). Vapor-phase p-ethylphenol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 9 hours(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a flavor and to make pharmaceuticals, dyes, and antioxidants (used in rubber and polymers); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: SYNTHETIC FLAVOR Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 4-Ethylphenol is contained in the xylenol fraction boiling between ca. 205 and 225 °C obtained from tar phenols, which is used, for example, for the production of phenolic resins. A xylenol fraction boiling between 216 and 218 °C containing predominantly 3- and 4-ethylphenol is obtained from brown coal low-temperature tar and used in the varnish industry. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Pure 4-ethylphenol is the starting material for the production of 4-vinylphenol and of various antioxidants (eg, 2,6-di-t-butyl-4-ethylphenol and 2,2'-methylenebis(6-t-butyl-4-ethylphenol)), which are used in rubber and polymers. 4-Ethylphenol is an intermediate for pharmaceuticals and dyes. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 4-ETHYLPHENOL

INCI name

4-ETHYLPHENOL

Description

4-Ethylphenol

Record provenance

Inventory reference
39919
Imported identity
4-ETHYLPHENOL
Source update
02/03/2011
European Commission CosIng source notes
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Key data

CAS
123-07-9
EC
204-598-6
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

4-ETHYLBENZALDEHYDEPERFUMING
4-ETHYLGUAIACOLPERFUMING
4-ETHYLOCTA-2,4-DIENOIC ACIDPERFUMING
4-ETHYLOCTANOIC ACIDPERFUMING
4-FORMYL-2-METHOXYPHENYL ISOBUTYRATEPERFUMING
4-METHYL-1-OXASPIRO-4-UNDECANOLPERFUMING
4-METHYL-1-OXASPIROUNDECENEPERFUMING
4-METHYL-1-PHENYL-2-PENTANOLPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How 4-ETHYLPHENOL appears in the CosIng inventory

The CosIng inventory lists 4-ETHYLPHENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

4-ETHYLPHENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

4-ETHYLPHENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 4-ETHYLPHENOL carries the following function designation(s):

CAS 123-07-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for 4-ETHYLPHENOL

This page reproduces the CosIng inventory entry for 4-ETHYLPHENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 4-ETHYLPHENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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