Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
InventoryRef 3983602/03/2011

ETHYL BUTYRATE

Ethyl butanoate

ETHYL BUTYRATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI CheckerCompare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sourcesSearch every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 105-54-4
CAS 105-54-4PubChem CID 7762

Ethyl butyrate

Ethyl butyrate is a butyrate ester resulting from the formal condensation of the hydroxy group of ethanol with the carboxy group of butyric acid. It has a role as a plant metabolite. It is functionally related to an ethanol. — ChEBI

IUPAC name
ethyl butanoate
Molecular formula
C6H12O2
Molecular weight
116.16 g/mol
Exact mass
116.083729621 Da
XLogP3
1.3
Topological polar surface area
26.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Butyric acid ethyl esterEthyl n-butyrateButanoic acid, ethyl esterEthyl n-butanoateButyric etherButanoic acid ethyl esterButyric esterButyric acid, ethyl ester
16 more reported names
FEMA No. 2427UFD2LZ005DNSC-8857CHEBI:88764RefChem:5809203-306-4n-Butyric acid ethyl esterEthyl 1-butyrateNSC 8857Ethyl ester of butanoic acidEthyl Butyrate, Standard For GcFEMA Number 2427Ethyl butyrate (natural)CCRIS 6554HSDB 406EINECS 203-306-4
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:88764

ethyl butyrate

A butyrate ester resulting from the formal condensation of the hydroxy group of ethanol with the carboxy group of butyric acid.

Formula
C6H12O2
Average mass
116.160 g/mol
Monoisotopic mass
116.08373 Da
Formal charge
0
  • butyrate ester — is a (CHEBI:50477)
  • plant metabolite — has role (CHEBI:76924)
  • ethanol — has functional parent (CHEBI:16236)
  • plant metabolite — has role (CHEBI:76924)
  • butyrate ester — is a (CHEBI:50477)
Additional curated names
ethyl butanoateButanoic acid ethyl esterButyric acid ethyl esterEthyl 1-butyrateEthyl ester of butanoic acidEthyl n-butanoateEthyl n-butyraten-Butyric acid ethyl ester
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-11-06. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7762

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: INHALATION: move victim to fresh air and call a physician; give artificial respiration if necessary.; INGESTION: induce vomiting and call a physician.; EYES: flush with water for at least 15 min.; SKIN: flush with water; wash with soap and water. (USCG, 1999) Source: CAMEO Chemicals
  • ERG2024, Guide 130 (Ethyl butyrate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Note: This chemical does not meet GHS hazard criteria for 0.3% (6 of 2073) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (99.7%): Flammable liquid and vapor [Warning Flammable liquids]; H319 (13.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264+P265, P280, P303+P361+P353, P305+P351+P338, P337+P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2073 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 6 of 2073 reports by companies.; There are 12 notifications provided by 2067 of 2073 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P319, P321, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Ethyl Butyrate is a colorless liquid. It is used in manufacturing artificial rum; perfumery; the alcoholic solution constitutes the so-called "pineapple oil". It is also used in flavoring extracts, solvent mixture for cellulose esters and ethers. HUMAN EXPOSURE AND TOXICITY: Tested at 5% in petrolatum, ethyl butyrate produced no irritation after a 48 hr closed-patch test in 25 human subjects. ANIMAL STUDIES: Ethyl butyrate applied full strength to intact or abraded rabbit skin for 24 hr under occlusion was moderately irritating. In rabbits admin of 2.14 mL/kg caused increase in respiratory volume. In vitro it has been shown to have a hemolytic effect slightly greater than that of methyl butyrate. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 8 was calculated in fish for ethyl n-butyrate(SRC), using an estimated log Kow of 1.85(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from a structure estimation method(2), indicates that ethyl nbutyrate is expected to have very high mobility in soil(SRC). Volatilization of ethyl n-butyrate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.4X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 14.0 mm Hg(3), and water solubility, 4,900 mg/L(4). Ethyl n-butyrate is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Ethyl n-butyrate has been classified as readily biodegradable as estimated by results from analogous compounds in the Japanese MITI test(5), suggesting that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 20(SRC), determined from a structure estimation method(2), indicates that ethyl n-butyrate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.4X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 14.0 mm Hg(4), and water solubility, 4,900 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 5 hrs and 5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 8(SRC), from an estimated log Kow of 1.85(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Ethyl n-butyrate has been classified as readily biodegradable as estimated by results from analogous compounds in the Japanese MITI test(7), suggesting that biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl n-butyrate, which has a vapor pressure of 14 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl n-butyrate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 4.94X10-12 cu cm/molecule-sec at 25 °C(3). Ethyl n-butyrate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ETHYL BUTYRATE

INCI name

ETHYL BUTYRATE

Description

Ethyl butanoate

Record provenance

Inventory reference
39836
Imported identity
ETHYL BUTYRATE
Source update
02/03/2011
European Commission CosIng source notes
Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search

Search annex entries

Search the annex database for entries matching ETHYL BUTYRATE or related substances.

Key data

CAS
105-54-4
EC
203-306-4
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

ETHYL ANTHRANILATEPERFUMING
ETHYL BENZOYLACETATEPERFUMING
ETHYL BETA-NAPHTHYL ETHERPERFUMING
ETHYL BUTYL VALEROLACTONEPERFUMING, TONIC
ETHYL CAPRATEPERFUMING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
ETHYL CINNAMATEPERFUMING, UV ABSORBER
ETHYL CITRALPERFUMING
ETHYL CROTONATEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ETHYL BUTYRATE appears in the CosIng inventory

The CosIng inventory lists ETHYL BUTYRATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ETHYL BUTYRATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ETHYL BUTYRATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ETHYL BUTYRATE carries the following function designation(s):

CAS 105-54-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Open INCI Checker

Source note for ETHYL BUTYRATE

This page reproduces the CosIng inventory entry for ETHYL BUTYRATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ETHYL BUTYRATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sourcesView updates

Tools & next steps

Check your formula

Scan a full INCI list to detect ETHYL BUTYRATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to ETHYL BUTYRATE, its identifiers or nearby name variants.

Search