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CAS 1139-30-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3929502/03/2011

CARYOPHYLLENE OXIDE

(1R-(1R*,4R*,6R*,10S*))-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane; beta-Caryophyllene oxide

CARYOPHYLLENE OXIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1139-30-6

CAS 1139-30-6PubChem CID 1742210

Caryophyllene oxide

Caryophyllene oxide is an epoxide. It has a role as a metabolite. — ChEBI

IUPAC name: (1R,4R,6R,10S)-4,12,12-trimethyl-9-methylidene-5-oxatricyclo[8.2.0.04,6]dodecane

Molecular formula: C15H24O
Molecular weight: 220.35 g/mol
Exact mass: 220.182715385 Da
XLogP3: 3.6
Topological polar surface area: 12.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 4

Also known as

beta-Caryophyllene oxideCaryophylene oxideEpoxycaryophyllenetrans-caryophyllene oxideS2XU9K448U(-)-BETA-CARYOPHYLLENE EPOXIDEFEMA NO. 4085(1R,4R,6R,10S)-4,12,12-trimethyl-9-methylidene-5-oxatricyclo(8.2.0.04,6)dodecane

16 more reported names

RefChem:29964214-519-7(-)-Caryophyllene oxide(-)Carophyllene oxideCaryophyllene epoxideCARYOPHYLLENEOXIDE(1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane(-)-Epoxycaryophyllene.beta.-Caryophyllene oxide(-)-EpoxydihydrocaryophylleneepoxideEugenol EP Impurity C(-)-.beta.-Caryophyllene epoxide(1R,4R,6R,10S)-4,12,12-TRIMETHYL-9-METHYLIDENE-5-OXATRICYCLO[8.2.0.0?,?]DODECANE5-Oxatricyclo(8.2.0.0(4,6))dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-5-Oxatricyclo(8.2.0.04,6)dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:67818
ChEMBL:CHEMBL508894
EPA DTXSID:DTXSID4051586
PubMed:33334892
PubMed:21832210
PubMed:21480511
PubMed:21438586
PubMed:18802628
PubMed:12562636
PubMed:12504350
PubMed:11774303
PubMed:8924604
PubMed:8109920

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match1742210

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Fine colorless crystals; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Colourless solid; Sweet fruity aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: Insoluble in water; Soluble in fat Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: Soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Note: This chemical does not meet GHS hazard criteria for 18.4% (59 of 320) of reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (45.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (45.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H411 (68.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 320 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 59 of 320 reports by companies.; There are 5 notifications provided by 261 of 320 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Sources/Uses: Used as a fragrance and flavoring agent; Extracted from peucedanum dhana seeds; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: POTENTIAL INSECT ATTRACTANT Source: Hazardous Substances Data Bank (HSDB)
Uses: FRAGRANCE & FLAVORING AGENT Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CARYOPHYLLENE OXIDE

INCI name

CARYOPHYLLENE OXIDE

Description

(1R-(1R*,4R*,6R*,10S*))-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane; beta-Caryophyllene oxide

Record provenance

Inventory reference: 39295
Imported identity: CARYOPHYLLENE OXIDE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for CARYOPHYLLENE OXIDE

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Key data

CAS

1139-30-6

214-519-7

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

CARVONEFLAVOURING, FRAGRANCE, PERFUMING

CARVONE OXIDEPERFUMING

CARYOPHYLLENE ACETATEPERFUMING

CARYOPHYLLENE ALCOHOLPERFUMING

CASTOR OIL HYDROGENATED ETHOXYLATEDPERFUMING

CASTOREUM OILPERFUMING

CEDRELA ODORATA WOOD EXTRACTPERFUMING

CEDRELA ODORATA WOOD OILPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CARYOPHYLLENE OXIDE appears in the CosIng inventory

The CosIng inventory lists CARYOPHYLLENE OXIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CARYOPHYLLENE OXIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CARYOPHYLLENE OXIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CARYOPHYLLENE OXIDE carries the following function designation(s):

PERFUMING

CAS 1139-30-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CARYOPHYLLENE OXIDE

This page reproduces the CosIng inventory entry for CARYOPHYLLENE OXIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CARYOPHYLLENE OXIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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