Is CARVACROL safe to use in EU cosmetics?

CARVACROL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 499-75-2?

CAS 499-75-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CARVACROL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3928515/10/2010

CARVACROL

2-Methyl-5-(1-methylethyl)phenol; 2-Hydroxy-p-cymene; 5-Isopropyl-o-cresol

CARVACROL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 499-75-2

CAS 499-75-2PubChem CID 10364

Carvacrol

Carvacrol is a phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1). It has a role as a TRPA1 channel agonist, a volatile oil component, an antimicrobial agent, an agrochemical and a flavouring agent. It is a p-menthane monoterpenoid, a member of phenols and a botanical anti-fungal agent. It derives from a hydride of a p-cymene. — ChEBI

IUPAC name: 2-methyl-5-propan-2-ylphenol

Molecular formula: C10H14O
Molecular weight: 150.22 g/mol
Exact mass: 150.104465066 Da
XLogP3: 3.1
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

5-Isopropyl-2-methylphenolIsopropyl-o-cresolAntioxine2-p-Cymenol5-Isopropyl-o-cresol2-Hydroxy-p-cymenePhenol, 2-methyl-5-(1-methylethyl)-Karvakrol

16 more reported names

p-Cymen-2-ol2-Methyl-5-isopropylphenol3-Isopropyl-6-methylphenolp-Cymene, 2-hydroxy-1-Hydroxy-2-methyl-5-isopropylbenzeneFEMA No. 2245Phenol, 5-isopropyl-2-methyl-1-Methyl-2-hydroxy-4-isopropylbenzeneDENTOLNSC-61889B1J4V995QCHEBI:3440RefChem:5653207-889-6o-Thymol2-Methyl-5-(1-methylethyl)phenol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3440
ChEMBL:CHEMBL281202
EPA DTXSID:DTXSID6042074
PubMed:31124249
PubMed:24387763
PubMed:23800587
PubMed:23111348
PubMed:23050016
PubMed:23049787
PubMed:23030436
PubMed:23025190
PubMed:23017418
PubMed:22983292
PubMed:22980020
PubMed:22970569

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CARVACROL

INCI name

CARVACROL

Description

2-Methyl-5-(1-methylethyl)phenol; 2-Hydroxy-p-cymene; 5-Isopropyl-o-cresol

Record provenance

Inventory reference: 39285
Imported identity: CARVACROL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CARVACROL

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Key data

CAS

499-75-2

207-889-6

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#5560 · CARVACROL

Ingredients with overlapping formulation functions

CARUM CARVI FRUIT OILFRAGRANCE, PERFUMING

CARUM CARVI SEED OILFRAGRANCE, PERFUMING

CARUM PETROSELINUM HERB EXTRACTPERFUMING

CARUM PETROSELINUM SEED OILFRAGRANCE, PERFUMING, SKIN CONDITIONING

CARVEOLPERFUMING

CARVONEFLAVOURING, FRAGRANCE, PERFUMING

CARVONE OXIDEPERFUMING

CARYOPHYLLENE ACETATEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CARVACROL appears in the CosIng inventory

The CosIng inventory lists CARVACROL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CARVACROL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CARVACROL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CARVACROL carries the following function designation(s):

PERFUMING

CAS 499-75-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CARVACROL

This page reproduces the CosIng inventory entry for CARVACROL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CARVACROL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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