InventoryRef 3906902/03/2011
ANISOLE
Methoxybenzene; Phenol Methyl Ether
ANISOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 100-66-3PubChem CID 7519
Anisole
Anisole appears as a clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent. — CAMEO Chemicals
- IUPAC name
- anisole
- Molecular formula
- C7H8O
- Molecular weight
- 108.14 g/mol
- Exact mass
- 108.057514874 Da
- XLogP3
- 2.1
- Topological polar surface area
- 9.2 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
MethoxybenzeneMethyl phenyl etherBenzene, methoxy-PhenoxymethaneAnisolPhenyl methyl etherAnizolPhenol methyl ether
16 more reported names
Ether, methyl phenylBenzene, methoxyFEMA No. 2097B3W693GAZHNSC-7920CHEBI:16579RefChem:5555202-876-14-methoxybenzeneHSDB 44Methoxy-Benzenemethylphenyl etherNSC 7920Ether, methyl phenyl-FEMA Number 2097EINECS 202-876-1
External database identifiers
- ChEBI:CHEBI:16579
- ChEBI:CHEBI:192244
- ChEMBL:CHEMBL278024
- EPA DTXSID:DTXSID4041608
- PubMed:23125657
- PubMed:23074909
- PubMed:23049688
- PubMed:23022280
- PubMed:23019157
- PubMed:23008069
- PubMed:22999809
- PubMed:22968765
- PubMed:22948565
- PubMed:22904976
- PubMed:22904855
- PubMed:22876948
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:16579
anisole
A monomethoxybenzene that is benzene substituted by a methoxy group.
- Formula
- C7H8O
- Average mass
- 108.140 g/mol
- Monoisotopic mass
- 108.05751 Da
- Formal charge
- 0
- monomethoxybenzene — is a (CHEBI:25235)
- plant metabolite — has role (CHEBI:76924)
- plant metabolite — has role (CHEBI:76924)
- monomethoxybenzene — is a (CHEBI:25235)
Additional curated names
anisoleAnisolAnisoleMethoxybenzeneMethyl phenyl etherPhenol methyl ether
Cross-references from this source
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-10-23. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7519
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 887 °F (475 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 475 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 155.5 °C AT 760 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 153.00 to 155.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 155 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 154 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 153.8 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: MOBILE LIQUID, CLEAR STRAW COLOR Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.9956 AT 18 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: PER CENT IN SATURATED AIR: 0.41; DENSITY OF SATURATED AIR: 1.1 (AIR= 1) Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.99 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.990-0.993 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 1.515 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 125 °F (NFPA, 2010) Source: CAMEO Chemicals
- Flash Point: 52 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 125 °F (52 °C) (OPEN CUP) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 52 °C o.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: Log Kow = 2.11 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 2.11 Source: Human Metabolome Database (HMDB)
- LogP: 2.11 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -37.3 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -37.5 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -37 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -37.3 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: SWEET ANISE-LIKE ODOR Source: Hazardous Substances Data Bank (HSDB)
- Odor: Agreeable aromatic odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Spicy-sweet Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Anisole appears as a clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless to yellow liquid; [ICSC] Clear colorless liquid; Insoluble in water; [MSDSonline] Spicy, sweet odor; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colourless liquid, Phenolic anise-like aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: INDEX OF REFRACTION: 1.51791 AT 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.515-1.518 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: SOLUBLE IN ALCOHOL AND ETHER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: VERY SOLUBLE IN ACETONE Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility = 1520 mg/L Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility = 10,400 mg/L Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility = 143 mg/L Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 1.04 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water: poor Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: Insoluble in water, soluble in oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 3.54 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 0.472 kPa (3.54 mm Hg) @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 25 °C: 0.47 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 10 [mm Hg] @42.2 °C Source: PAC Chemical Database, U.S. Department of Energy
- Viscosity: 1.52 centipoise at 15 °C; 0.778 centipoise at 30 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:; Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 128 (Anisole): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2013) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H315 (76.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (78.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336 (13.1%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2013 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 2013 reports by companies.; There are 28 notifications provided by 2012 of 2013 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: Using its log Kow, 2.11(2), one estimates a BCF of 24 for anisole using a recommended regression equation(3). The bioconcentration of anisole in aquatic organisms was determined in a model aquatic ecosystem maintained at 26.7 °C with 12 hr of simulated daylight exposure(1). After 24 hr exposure, the ecological magnification for anisole was (organism, bioaccumulation factor): fish, 22; mosquito larva, 27; algae, 563; daphnia, 771; snails, 899(1). There were signs of considerable metabolism in all species. O-dealkylate occurred in fish and snail, hydroxylation to o- and p-methoxyphenols occurred in all species except daphnia, and conjugation occurred in alga and snails(1). According to a recommended classification scheme(4), this BCF value and its metabolism in aquatic organisms would indicate that anisole has a low potential for bioconcentration in fish and aquatic organisms(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(2), the experimentally-determined Koc value for anisole of 35(1) suggests that it will be highly mobile in soil and may leach(SRC). Its estimated Henry's Law constant(3), 4.35X10-3 atm-cu m/mole(SRC), vapor pressure, 3.4 mm Hg at 25 °C(5), and low adsorptivity to soil indicate that volatilization may be an important fate process from both moist and dry soil surfaces(4,SRC). Anisole has been demonstrated to be readily biodegradable in screening tests(6-8) and therefore may readily biodegrade in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Anisole should volatilize from water based on its estimated Henry's Law constant of 4.4X10-3 atm-cu m/mole(SRC), derived from a fragment constant estimation method(3). Estimated half-lives for a model river and model lake are 3.2 hr and 4.2 days, respectively(4,SRC). Anisole has been demonstrated to be readily biodegradable in screening tests(5,6) and therefore may biodegrade in natural water(SRC). When anisole was added to a model aquatic ecosystem with fish, mosquito larva, alga, daphnia, and snails and incubated for 24 hr, the concentration of anisole was considerably reduced (by approximately 93%) and degradation products were found in the water(1). A Russian study reported that anisole was stable in water for 4 days(2). The details of the study were not available. According to a recommended classification scheme(8), experimental bioaccumulation factors obtained from a model aquatic ecosystem along with evidence of metabolism in aquatic organisms(1) suggests that bioaccumulation of anisole should not be a concern(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a theory of gas/particle partitioning of semivolatile organic compounds in the atmosphere(2), anisole, which has a vapor pressure of 3.5 mm Hg at 25 °C(3) will exist in the ambient atmosphere as a vapor(SRC). Vapor-phase anisole is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 22 hr(1,SRC). Anisole's water solubility in water is 1520 mg/L(4), and therefore it may be washed out of the atmosphere by rain(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Industry Uses: Solvent Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a vermicide, flavoring agent, solvent, and heat transfer medium; Used in the production of fragrances, pharmaceuticals, and other organic compounds; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: IN PERFUMERY; IN ORGANIC SYNTHESES Source: Hazardous Substances Data Bank (HSDB)
- Uses: VERMICIDE; FLAVORING Source: Hazardous Substances Data Bank (HSDB)
- Uses: Important intermediate in the manufacture of organic compounds, for example fragrances and pharmaceuticals. It is also used as a solvent and heat transfer medium. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ANISOLE
INCI name
ANISOLE
Description
Methoxybenzene; Phenol Methyl Ether
Record provenance
- Inventory reference
- 39069
- Imported identity
- ANISOLE
- Source update
- 02/03/2011
Annex records for ANISOLE
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How ANISOLE appears in the CosIng inventory
The CosIng inventory lists ANISOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ANISOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
ANISOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, ANISOLE carries the following function designation(s):
CAS 100-66-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for ANISOLE
This page reproduces the CosIng inventory entry for ANISOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research ANISOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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