AMYL ETHYL KETONE
Octan-3-one
AMYL ETHYL KETONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
3-Octanone
3-octanone is a dialkyl ketone that is octane in which the two methylene protons at position 3 have been replaced by an oxo group. It has a role as an antifeedant, an insect attractant, a toxin, a biomarker, a plant metabolite, a fungal metabolite and a human urinary metabolite. It derives from a hydride of an octane. — ChEBI
- IUPAC name
- octan-3-one
- Molecular formula
- C8H16O
- Molecular weight
- 128.21 g/mol
- Exact mass
- 128.120115130 Da
- XLogP3
- 2.3
- Topological polar surface area
- 17.1 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:80946
- ChEMBL:CHEMBL2269087
- EPA DTXSID:DTXSID3041954
- PubMed:27829300
- PubMed:22506397
- PubMed:22396667
- PubMed:22259435
- PubMed:22169393
- PubMed:22075025
- PubMed:22072908
- PubMed:21961006
- PubMed:21876772
- PubMed:21823126
- PubMed:21799756
- PubMed:21720824
Evidence from additional scientific databases
EMBL-EBI ChEBI
3-octanone
A dialkyl ketone that is octane in which the two methylene protons at position 3 have been replaced by an oxo group.
- Formula
- C8H16O
- Average mass
- 128.215 g/mol
- Monoisotopic mass
- 128.12012 Da
- Formal charge
- 0
- dialkyl ketone — is a (CHEBI:18044)
- human urinary metabolite — has role (CHEBI:84087)
- insect attractant — has role (CHEBI:24850)
- fungal metabolite — has role (CHEBI:76946)
- antifeedant — has role (CHEBI:22583)
- plant metabolite — has role (CHEBI:76924)
- biomarker — has role (CHEBI:59163)
- toxin — has role (CHEBI:27026)
- octane — has parent hydride (CHEBI:17590)
- human urinary metabolite — has role (CHEBI:84087)
- insect attractant — has role (CHEBI:24850)
- fungal metabolite — has role (CHEBI:76946)
- antifeedant — has role (CHEBI:22583)
- plant metabolite — has role (CHEBI:76924)
- biomarker — has role (CHEBI:59163)
- toxin — has role (CHEBI:27026)
- dialkyl ketone — is a (CHEBI:18044)
- 1139896 Source: PubMed
- 13633437 Source: PubMed
- 21970810 Source: PubMed
- 24421258 Source: PubMed
- 24634568 Source: PubMed
- 25103776 Source: PubMed
- 25174554 Source: PubMed
- 25524148 Source: PubMed
- 25767084 Source: PubMed
- 26017013 Source: PubMed
- 26372442 Source: PubMed
- 26563202 Source: PubMed
- 26567951 Source: PubMed
- 26593566 Source: PubMed
- 27593501 Source: PubMed
- 27748984 Source: PubMed
- 27829300 Source: PubMed
- 28074245 Source: PubMed
- 28232862 Source: PubMed
- 28490051 Source: PubMed
- 28717894 Source: PubMed
- 28901104 Source: PubMed
- 31238146 Source: PubMed
- 36652525 Source: PubMed
Additional curated names
Cross-references from this source
- CAS: 106-68-3 — KEGG COMPOUND
- CAS: 106-68-3 — ChemIDplus
- CAS: 106-68-3 — NIST Chemistry WebBook
- REGISTRY_NUMBER: 1700021 — Reaxys
- MANUAL_X_REF: 3-Octanone — Wikipedia
- MANUAL_X_REF: C00034765 — KNApSAcK
- MANUAL_X_REF: C17145 — KEGG COMPOUND
- MANUAL_X_REF: FDB005050 — FooDB
- MANUAL_X_REF: HMDB0031295 — HMDB
- MANUAL_X_REF: LMFA12000055 — LIPID MAPS
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2023-02-02. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 332.6 to 334.4 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 167.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 167.00 to 170.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 169-173 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.822 (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.820-0.824 at 20 °C/20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.817-0.821 (23 °C) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: 115 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 59 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Melting Point: -23.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Odor: Mild fruity odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Ethyl n-amyl ketone appears as a clear colorless liquid with a pungent odor. Insoluble in water and partially soluble in alcohol. Vapors are denser than air and may have a narcotic effect in high concentrations. Used in making perfumes and as a solvent for nitrocellulose and vinyl resins. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless to slightly yellow liquid; Pungent, somewhat fruity odor; [Merck Index] Colorless liquid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless, oily liquid with a herbaceous, fruity warm odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.4150 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.413-1.418 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Slightly miscible (USCG, 1999) Source: CAMEO Chemicals
- Solubility: Miscible with ethanol, ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with oxygenated solvents. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 2.6X10+3 mg/L at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 2.6 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Solubility: soluble in most common organic solvents; insoluble in water Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 1 ml in 5 ml 60% alcohol; 1 ml in 3 ml 70% alcohol (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 2.0 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 2 mm Hg at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- First Aid: Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:; Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024) Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 0.3% (5 of 1778) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (99.7%): Flammable liquid and vapor [Warning Flammable liquids] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1778 reports by companies from 9 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 5 of 1778 reports by companies.; There are 8 notifications provided by 1773 of 1778 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264, P280, P302+P352, P303+P361+P353, P321, P332+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Environmental Bioconcentration: An estimated BCF of 7 was calculated in fish for 3-octanone(SRC), using a water solubility of 2600 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 58(SRC), determined from a water solubility of 2600 mg/L(2) and a regression-derived equation(3), indicates that 3-octanone is expected to have high mobility in soil(SRC). Volatilization of 3-octanone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 2.0 mm Hg(2), and water solubility(2). 3-Octanone is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Under aerobic conditions, this compound may biodegrade; 3-octanone at 500 mg/L reached an average of 1.1, 2.0, and 3.4% of the theoretical oxygen demand within 6, 12, and 24 hours when inoculated with activated sludge(4). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 58(SRC), determined from a water solubility of 2600 mg/L(2) and a regression-derived equation(3), indicates that 3-octanone is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 2.0 mm Hg(2), and water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 11 hours and 6.8 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 7(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Under aerobic conditions, this compound may biodegrade; 3-octanone at 500 mg/L reached an average of 1.1, 2.0, and 3.4% of the theoretical oxygen demand within 6, 12, and 24 hours when inoculated with activated sludge(5). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 3-octanone, which has a vapor pressure of 2.0 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 3-octanone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 41 hours(SRC), calculated from its rate constant of 9.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 3-Octanone contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight(4). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Fragrance Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used in lavender perfumes and flavoring agents; [Merck Index] Used as a solvent for nitrocellulose and vinyl resins; [CAMEO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Derivatives: 3-octanol Source: Hazardous Substances Data Bank (HSDB)
- Uses: Reported uses (ppm): FEMA, 1994); Table: Reported uses (ppm): FEMA, 1994) [Table#5381] Source: Hazardous Substances Data Bank (HSDB)
- Uses: EPA Pesticides Inerts: List 3, Inerts of unknown toxicity Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for AMYL ETHYL KETONE
INCI name
AMYL ETHYL KETONE
Description
Octan-3-one
Record provenance
- Inventory reference
- 39039
- Imported identity
- AMYL ETHYL KETONE
- Source update
- 02/03/2011
Annex records for AMYL ETHYL KETONE
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How AMYL ETHYL KETONE appears in the CosIng inventory
The CosIng inventory lists AMYL ETHYL KETONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
AMYL ETHYL KETONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for AMYL ETHYL KETONE
This page reproduces the CosIng inventory entry for AMYL ETHYL KETONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research AMYL ETHYL KETONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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