InventoryRef 3899802/03/2011
ACETALDEHYDE DIETHYL ACETAL
1,1-Diethoxyethane
ACETALDEHYDE DIETHYL ACETAL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 105-57-7PubChem CID 7765
Acetal
Acetal appears as a clear colorless liquid with a pleasant odor. Boiling point 103-104 °C. Flash point -5 °F. Density 0.831 g / cm3. Slightly soluble in water. Vapors heavier than air. Moderately toxic and narcotic in high concentrations. — CAMEO Chemicals
- IUPAC name
- 1,1-diethoxyethane
- Molecular formula
- C6H14O2
- Molecular weight
- 118.17 g/mol
- Exact mass
- 118.099379685 Da
- XLogP3
- 0.8
- Topological polar surface area
- 18.5 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Acetaldehyde diethyl acetalDiethyl acetalDiethylacetalEthane, 1,1-diethoxy-DiaethylacetalAcetaleEthylidene diethyl etherAcetal diethylique
16 more reported names
Acetaal1,1-Dietossietano1,1-Diethoxy-ethaan1,1-Diaethoxy-aethanAcetaldehyde, diethyl acetalEthylidenediethyl etherAcetaldehyde ethyl acetalUSAF DO-45FEMA No. 20025G14F9E2HBNSC-7624NSC7624AcetalsRefChem:551479CHEBI:59769203-310-6
External database identifiers
- ChEBI:CHEBI:179533
- ChEMBL:CHEMBL1338583
- EPA DTXSID:DTXSID6030607
- PubMed:22649934
- PubMed:21375340
- PubMed:21211062
- PubMed:21053928
- PubMed:20735852
- PubMed:20689702
- PubMed:19662831
- PubMed:18783210
- PubMed:18498170
- PubMed:18367362
- PubMed:17497014
- PubMed:16704220
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:179533
1,1-Diethoxyethane
- Formula
- C6H14O2
- Average mass
- 118.176 g/mol
- Monoisotopic mass
- 118.09938 Da
- Formal charge
- 0
- acetal — is a (CHEBI:59769)
- acetal — is a (CHEBI:59769)
Additional curated names
1,1-diethoxyethane
Cross-references from this source
- CAS: 105-57-7 — ChemIDplus
- MANUAL_X_REF: 13835836 — ChemSpider
- MANUAL_X_REF: HMDB0031644 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7765
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 446 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 446 °F (230 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 230 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 216 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 102.7 °C AT 760 MM HG; 66.3 °C AT 200 MM HG; 39.8 °C AT 60 MM HG; 31.9 °C AT 40 MM HG; 19.6 °C AT 20 MM HG; +8.0 °C AT 10 MM HG; -2.3 °C AT 5 MM HG; -23 °C AT 1.0 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 102.00 to 104.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 103 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 102 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: COLORLESS LIQUID Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.831 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.8254 AT 20 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.83 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.822-0.831 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: -5 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: -20.5 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: -5 °F (-21 °C) (CLOSED CUP) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: -21 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: Log Kow = 0.84 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 0.84 Source: Human Metabolome Database (HMDB)
- LogP: 0.84 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -148 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: -100 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -100 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -100 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Odor: PUNGENT, GREEN, WOODY SOLVENT ODOR Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Acetal appears as a clear colorless liquid with a pleasant odor. Boiling point 103-104 °C. Flash point -5 °F. Density 0.831 g / cm3. Slightly soluble in water. Vapors heavier than air. Moderately toxic and narcotic in high concentrations. Source: CAMEO Chemicals
- Physical Description: Colorless, volatile liquid with an agreeable odor; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH PUNGENT ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: volatile colourless liquid with a refreshing, pleasant, fruity-green odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: INDEX OF REFRACTION: 1.38193 AT 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.378-1.386 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: MISCIBLE WITH ALCOHOL, 60% ALCOHOL, ETHER; SOL IN HEPTANE, METHYLCYCLOHEXANE, ETHYL ACETATE; PROPYL, ISOPROPYL, BUTYL & ISOBUTYL ALCOHOLS; 100 G WATER DISSOLVE 5 G ACETAL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOL IN CHLOROFORM Source: Hazardous Substances Data Bank (HSDB)
- Solubility: sol in acetone Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water Solubility = 4.4X10+4 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 44 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml: 5.0 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: slightly soluble in water; miscible with most organic solvents, oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: miscible (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 56.87 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Vapor Pressure: 27.6 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 27.6 mm Hg at 25 °C /from experimentally derived coefficients/ Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 2.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Viscosity: Liquid viscosity = 2.1531X10-3 Pa.s @ 200 deg K Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: INGESTION: Call a physician. Keep victim warm.; EYES: Flush with running water for at least 15 minutes.; SKIN: Remove contaminated clothing and shoes. Flush affected areas with plenty of water. Wash with soap and water.; INHALATION: Move victim to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen. (USCG, 1999) Source: CAMEO Chemicals
- ERG2024, Guide 127 (Acetal): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264, P264+P265, P280, P302+P352, P303+P361+P353, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (98.7%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H315 (> 99.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (97.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P264, P264+P265, P280, P302+P352, P303+P361+P353, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1842 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: NITE-CMC
- Precautionary Statement Codes: P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF value of 2.6 was calculated for acetal(SRC), using an experimental log Kow of 0.84(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will be low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 68(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that acetal will have high mobility in soil(SRC). Volatilization of acetal may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 9.75X10-5 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(4) and water solubility(5), and from dry soil surfaces(SRC) based on an experimental vapor pressure of 27.6 mm Hg(5). Insufficient data are available to determine the rate or importance of biodegradation of acetal in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 68(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that acetal would not adsorb to suspended solids and sediment(SRC) in the water. Acetal would volatilize from water surfaces based on an estimated Henry's Law constant of 9.75X10-5 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(4) and water solubility(5). Estimated half-lives for a model river and model lake are 13 hours and 7.3 days, respectively(3,SRC). An estimated BCF value of 2.6(3,SRC), from an experimental log Kow(2), suggests that acetal will not bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(6). Acetals are easily cleaved by dilute acids by the SN1 mechanism(7). However, they are extremely resistant to hydrolysis by bases(7). Therefore, hydrolysis of acetal is expected to be an important fate process in acidic water conditions(SRC). Insufficient data are available to determine the rate or importance of biodegradation of acetal in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a suggested classification scheme(1), an experimental vapor pressure of 27.6 mm Hg at 25 °C(2) indicates that acetal will exist in the vapor phase in the ambient atmosphere. Vapor-phase acetal is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 19.6 hours(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as a solvent for perfumes, flavors, and cosmetics; [HSDB] Used as an herbicide; [eChemPortal: ERMA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: SOLVENT; IN ORGANIC SYNTHESES; /SRP: FORMERLY/ HYPNOTIC Source: Hazardous Substances Data Bank (HSDB)
- Uses: SOLVENT IN PERFUMES Source: Hazardous Substances Data Bank (HSDB)
- Uses: SYNTHETIC FLAVORING INGREDIENT Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used in cosmetics Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ACETALDEHYDE DIETHYL ACETAL
INCI name
ACETALDEHYDE DIETHYL ACETAL
Description
1,1-Diethoxyethane
Record provenance
- Inventory reference
- 38998
- Imported identity
- ACETALDEHYDE DIETHYL ACETAL
- Source update
- 02/03/2011
Annex records for ACETALDEHYDE DIETHYL ACETAL
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How ACETALDEHYDE DIETHYL ACETAL appears in the CosIng inventory
The CosIng inventory lists ACETALDEHYDE DIETHYL ACETAL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ACETALDEHYDE DIETHYL ACETAL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
ACETALDEHYDE DIETHYL ACETAL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, ACETALDEHYDE DIETHYL ACETAL carries the following function designation(s):
CAS 105-57-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for ACETALDEHYDE DIETHYL ACETAL
This page reproduces the CosIng inventory entry for ACETALDEHYDE DIETHYL ACETAL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research ACETALDEHYDE DIETHYL ACETAL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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