USNIC ACID
2,6-Diacetyl-1,2,3,9b-tetrahydro-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
USNIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Source mapped Inventory entry; no linked annex rule | 0 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Prohibited Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Source mapped Official source mapped; ingredient rule not imported | 0 | Arabic and English |
Chemical identity and properties
Usnic Acid
Usnic acid is a furandione found uniquely in lichen that is used widely in cosmetics, deodorants, toothpaste and medicinal creams as well as some herbal products. Taken orally, usnic acid can be toxic and has been linked to instances of clinically apparent, acute liver injury. — LiverTox
- IUPAC name
- 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
- Molecular formula
- C18H16O7
- Molecular weight
- 344.3 g/mol
- Exact mass
- 344.08960285 Da
- XLogP3
- 1.4
- Topological polar surface area
- 118.0 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 7
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:2264
- ChEMBL:CHEMBL1375951
- EPA DTXSID:DTXSID0040123
- PubMed:38724177
- PubMed:37840363
- PubMed:32508146
- PubMed:31715134
- PubMed:27497765
- PubMed:27369375
- PubMed:25870318
- PubMed:25078063
- PubMed:23686521
- PubMed:23422721
- PubMed:23099095
- PubMed:22777745
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: ... yellowish /colored/ pigment. Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellow orthorombic prisms from acetone Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Crystalline yellow solid Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 2.88 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 204 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Yellow solid; [Merck Index] Yellow crystalline solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Solubility at 25 °C (g/100 ml): acetone, 0.77; ethyl acetate, 0.88; fural, 7.32; furfuryl alcohol, 1.21 Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility at 25 °C (g/100 ml): water, <0.01 Source: Hazardous Substances Data Bank (HSDB)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H301 (70.2%): Toxic if swallowed [Danger Acute toxicity, oral]; H302 (29.8%): Harmful if swallowed [Warning Acute toxicity, oral]; H400 (70.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (70.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P270, P273, P301+P316, P301+P317, P321, P330, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 94 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Sources/Uses: Antibacterial compound present in lichens; [Merck Index] Used as preservative and antibiotic (folk remedy); [HSDB] Used as a topical antibiotic; Workers exposed to lichens (forestry and horticulture) may develop allergic contact dermatitis. [Kanerva, p. 1845] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Activities with risk of exposure: Ingesting herbal remedies [Category: Food & Drugs] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Medicine: antibiotic /SRP: folk remedy/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Preservative Source: Hazardous Substances Data Bank (HSDB)
- Uses: Usnic acid is effective in vitro against ...anerobic bacteria. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for USNIC ACID
INCI name
USNIC ACID
Description
2,6-Diacetyl-1,2,3,9b-tetrahydro-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Record provenance
- Inventory reference
- 38848
- Imported identity
- USNIC ACID
- Source update
- 15/10/2010
Annex records for USNIC ACID
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How USNIC ACID appears in the CosIng inventory
The CosIng inventory lists USNIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
USNIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for USNIC ACID
This page reproduces the CosIng inventory entry for USNIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research USNIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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