Is UBIQUINONE safe to use in EU cosmetics?

UBIQUINONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

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InventoryRef 3880712/07/2019

UBIQUINONE

2,5-Cyclohexadiene-1,4-dione, 2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-, (all-E)-

UBIQUINONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 303-98-0

CAS 303-98-0PubChem CID 5281915

Coenzyme Q10

Coenzyme Q10 is a ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration. It has a role as a ferroptosis inhibitor, an antioxidant and a human metabolite. — ChEBI

IUPAC name: 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Molecular formula: C59H90O4
Molecular weight: 863.3 g/mol
Exact mass: 862.68391135 Da
XLogP3: 19.4
Topological polar surface area: 52.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

ubidecarenoneCoQ10ubiquinone-10Ubiquinone 50Ubiquinone 10Ubiquinone Q10UbidecarenonaBio-Quinone Q10

16 more reported names

Aqua Q10Unispheres Q 10UbidecarenonumPureSorb Q 40AdelirOristar ubqco-enzyme Q10Coenzyme q-199CoQ 10API-31510Q 199EJ27X76M46Ubidecarenone for system suitabilityBPM-31510NSC-140865API 31510

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:46245
ChEMBL:CHEMBL454801
EPA DTXSID:DTXSID6046054
PubMed:29190916
PubMed:20574076
PubMed:19281730
PubMed:19240848
PubMed:16551570
PubMed:12374491
PubMed:7599208
PubMed:7224

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 60684-33-5

CAS 60684-33-5PubChem CID 17572160

2-[(2E,6E,10E,14Z,18E,22E,26E,30Z,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

IUPAC name: 2-[(2E,6E,10E,14Z,18E,22E,26E,30Z,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Molecular formula: C59H90O4
Molecular weight: 863.3 g/mol
Exact mass: 862.68391135 Da
XLogP3: 19.4
Topological polar surface area: 52.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

ACTIUHUUMQJHFO-DQXDOXBUSA-NGS-6199

Open full PubChem record PubChem annotations 3D structure image

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for UBIQUINONE

INCI name

UBIQUINONE

INN name

Ubidecarenone [INN:JAN]

Description

2,5-Cyclohexadiene-1,4-dione, 2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-, (all-E)-

Record provenance

Inventory reference: 38807
Imported identity: UBIQUINONE
Source update: 12/07/2019

European Commission CosIng source notes

Annex records for UBIQUINONE

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Key data

CAS

303-98-0 / 1339-63-5 / 60684-33-5

206-147-9 / 215-668-0

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29598 · UBIQUINONE

Ingredients with overlapping formulation functions

TYROSYL HISTIDINE HCIANTIOXIDANT

TYROSYL HISTIDINE HCLANTIOXIDANT

UAPACA BOJERI LEAF EXTRACTANTIOXIDANT

UBIQUINOLANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

ULMUS DAVIDIANA BRANCH EXTRACTANTIOXIDANT, HUMECTANT, SKIN CONDITIONING

UMBELLIFERONEANTIOXIDANT; HUMECTANT; SKIN CONDITIONING - HUMECTANT

UNCARIA TOMENTOSA BARK EXTRACTANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

UNDECYLENOYL GRAPE SEED EXTRACTANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How UBIQUINONE appears in the CosIng inventory

The CosIng inventory lists UBIQUINONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

UBIQUINONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

UBIQUINONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, UBIQUINONE carries the following function designation(s):

CAS 303-98-0 / 1339-63-5 / 60684-33-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for UBIQUINONE

This page reproduces the CosIng inventory entry for UBIQUINONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research UBIQUINONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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