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InventoryRef 3872215/10/2010

TRIISOPROPANOLAMINE

1,1',1''-Nitrilotripropan-2-ol

TRIISOPROPANOLAMINE is linked to 1 EU annex record on this page. Inventory note: III/62.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Restricted entry found
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 122-20-3
CAS 122-20-3PubChem CID 24730

Triisopropanolamine

Triisopropanolamine is a white solid with slight odor of ammonia. Denser than water. — CAMEO Chemicals

IUPAC name
1-[bis(2-hydroxypropyl)amino]propan-2-ol
Molecular formula
C9H21NO3
Molecular weight
191.27 g/mol
Exact mass
191.15214353 Da
XLogP3
-0.5
Topological polar surface area
63.9 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

TIPATRIS(2-HYDROXYPROPYL)AMINETri-2-propanolamineTri-iso-propanolamineTris(2-propanol)amineTris(2-hydroxy-1-propyl)amine2-Propanol, 1,1',1''-nitrilotri-2-Propanol, 1,1',1''-nitrilotris-
16 more reported names
1,1',1''-Nitrilotri-2-propanolTriisopropanolaminW9EN9DLM981,1',1''-Nitrilotris(2-propanol)UNICHEM TIPANSC-40101,1',1''-Nitrilotris[2-propanol]204-528-4TiPlARefChem:1916971,1',1''-Nitrilotripropan-2-ol1,1',1''-Nitrilotris(propan-2-ol)NSC 40103,3',3''-Nitrilotri(2-propanol)Triisopropanolamine (mixture of isomers)Caswell No. 891
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match24730

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1735) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (98.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H412 (66.9%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P273, P280, P305+P351+P338, P337+P317, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1735 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1735 reports by companies.; There are 11 notifications provided by 1734 of 1735 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P264+P265, P271, P280, P304+P340, P305+P354+P338, P317, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Conclusion: The Panel concludes that Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed Isopropanolamines are safe as cosmetic ingredients in the present practices of use and concentration. The isopropanolamines should not be used in products containing N-nitrosating agents. Source: Cosmetic Ingredient Review (CIR)
  • Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: During a 6 week period using carp fish (Cyprinus carpio), BCF values of <0.06 and <0.57 were measured for triisopropanolamine at respective concentrations of 2.5 and 0.25 mg/L(1). According to a classification scheme(2), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triisopropanolamine is expected to have very high mobility in soil(SRC). The pKa of triisopropanolamine is 8.06(3), indicating that this compound will partially exist in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of triisopropanolamine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.8X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(2). Triisopropanolamine is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 9.75X10-6 mm Hg at 25 °C(4). Triisopropanolamine was found to be not readily biodegradable using the Japanese MIT test where triisopropanolamine had only a 3.4% BODT after 4 weeks(5). However, the results of other ready, inherent and simulation tests have indicated that triisopropanolamine is readily susceptible to biodegradation with CO2 the dominant degradation product u Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triisopropanolamine is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.8X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), a BCF value of <0.57 in carp fish(5) suggests the potential for bioconcentration in aquatic organisms is low(SRC). Triisopropanolamine was found to be not readily biodegradable using the Japanese MIT test where triisopropanolamine had only a 3.4% BODT after 4 weeks(6). However, the results of other ready, inherent and simulation tests have indicated that triisopropanolamine is readily susceptible to biodegradation with CO2 the dominant degradation product under aerobic conditions(7). In a lake water-sediment batch study, triisopropanolamine had a half-life of 14.3 days with 62% mineralization to CO2(7). Triisopropanolamine is expected to be stable to aqueous hydrolysis in the environment(8). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triisopropanolamine, which has a vapor pressure of 9.75X10-6 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase triisopropanolamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 3 hours(SRC), calculated from its rate constant of 1.2X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase triisopropanolamine may be removed from the air by wet or dry deposition(SRC). Triisopropanolamine absorbs light at wavelengths >290 nm(2) and may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Intermediate; Stabilizing agent; Not Known or Reasonably Ascertainable; pH regulating agent; Processing aids not otherwise specified; Other Source: EPA Chemical Data Reporting (CDR)
  • Cosmetic Ingredient Review Link: CIR ingredient: Triisopropanolamine Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as an emulsifying agent, rubber cross-linking agent, corrosion inhibitor in metal working fluids, and surfactant; [HSDB] Used in cyanide-free zinc plating and in the rubber industry; [CHEMINFO] Used in coatings (cross-linker and stabilizer) and pesticides (neutralizer and stabilizer); [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Machining [Category: Heat or Machine]; Electroplating [Category: Plate]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For Tris(2-hydroxypropyl)amine) (USEPA/OPP Pesticide Code: 004209) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Emulsifying agents. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Crosslinking agent (rubber); emulsifier/corrosion inhibitor (metal working fluids); surfactant/solubilising agent Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Color stabilizer for polyethylene formulations Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Triisopropanolamine is widely used as emulsifiers, stabilizers, surfactants and chemical intermediates. Major applications include: coatings as a cross-linker, acid neutralizer to improve product stability and pesticides as a neutralizer and to improve product stability. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIISOPROPANOLAMINE

INCI name

TRIISOPROPANOLAMINE

Description

1,1',1''-Nitrilotripropan-2-ol

Record provenance

Inventory reference
38722
Imported identity
TRIISOPROPANOLAMINE
Source update
15/10/2010
European Commission CosIng source notes

Key data

CAS
122-20-3
EC
204-528-4
Restriction
III/62
Function
BUFFERING
Stabilising the pH of an aqueous medium in a narrow range even if an acid or base is added. Altering and/or maintaining a cosmetic product's pH at the desired level.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29230 · TRIISOPROPANOLAMINE

Ingredients with overlapping formulation functions

TETRAHYDROXYETHYL ETHYLENEDIAMINEBUFFERING, CHELATING
TETRAPOTASSIUM PYROPHOSPHATEBUFFERING, CHELATING, ORAL CARE
TETRASODIUM PYROPHOSPHATEANTICAKING, BUFFERING, CHELATING, ORAL CARE
TRIETHANOLAMINEBUFFERING, FRAGRANCE, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING
TRIPOTASSIUM PHOSPHATEBUFFERING
TRIS BUFFERED SALINEBUFFERING
TRISODIUM PHOSPHATEBUFFERING, CHELATING
TRISODIUM SULFOSUCCINATEBUFFERING, CHELATING, SURFACTANT - CLEANSING, SURFACTANT - HYDROTROPE

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How TRIISOPROPANOLAMINE appears in the CosIng inventory

The CosIng inventory lists TRIISOPROPANOLAMINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIISOPROPANOLAMINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIISOPROPANOLAMINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for TRIISOPROPANOLAMINE reads: "III/62". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, TRIISOPROPANOLAMINE carries the following function designation(s):

CAS 122-20-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for TRIISOPROPANOLAMINE

This page combines the CosIng inventory entry for TRIISOPROPANOLAMINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research TRIISOPROPANOLAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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