Is SERINE safe to use in EU cosmetics?

SERINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does SERINE serve in cosmetics?

According to the EU CosIng inventory, SERINE carries the following function designation(s): ANTISTATIC, FRAGRANCE, HAIR CONDITIONING, SKIN CONDITIONING.

How do I check if my formula contains SERINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3766015/10/2010

SERINE

2-Amino-3-hydroxypropanoic acid

SERINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 302-84-1

CAS 302-84-1PubChem CID 617

DL-Serine

Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is a polar amino acid and an alpha-amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion. — ChEBI

IUPAC name: 2-amino-3-hydroxypropanoic acid

Molecular formula: C3H7NO3
Molecular weight: 105.09 g/mol
Exact mass: 105.042593085 Da
XLogP3: -3.1
Topological polar surface area: 83.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Serine, DL-00PAR1C66FNSC-9960NSC99602-azaniumyl-3-hydroxypropanoateSerine DL-RefChem:1083916206-130-6

16 more reported names

Serine DL-formH-DL-Ser-OHSERINE, (L)d,l-serineL-Serine-2-13c-15N2-amino-3-hydroxy-propanoic acidDL-2-Amino-3-hydroxypropionic AcidDL-SERINE [FCC]DL-Serine, analytical standardSERINE, L-[3-3H]DL-SERINE (1-13C)DL-Serine, Vetec(TM) reagent grade, 98%L-Serine-1,2-13C2SR-010000754742-Amion-3-hydroxypropionicacidF1652-0637

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17822
EPA DTXSID:DTXSID70859325
PubMed:22961244
PubMed:22747426
PubMed:22675391
PubMed:22655267
PubMed:22654749
PubMed:22652304
PubMed:22629167
PubMed:22610678
PubMed:22606313
PubMed:22590497
PubMed:22496310
PubMed:22476871

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 56-45-1

CAS 56-45-1PubChem CID 5951

L-Serine

L-serine is the L-enantiomer of serine. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a L-alpha-amino acid, a serine, a serine family amino acid and a proteinogenic amino acid. It is a conjugate base of a L-serinium. It is a conjugate acid of a L-serinate. It is an enantiomer of a D-serine. It is a tautomer of a L-serine zwitterion. — ChEBI

IUPAC name: (2S)-2-amino-3-hydroxypropanoic acid

Molecular formula: C3H7NO3
Molecular weight: 105.09 g/mol
Exact mass: 105.042593085 Da
XLogP3: -3.1
Topological polar surface area: 83.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 1

Also known as

serine(S)-2-Amino-3-hydroxypropanoic acid(S)-Serinebeta-HydroxyalanineL-(-)-SerineL-serSerinaL-Serin

16 more reported names

SER (IUPAC abbrev)Serinumalpha-Amino-beta-hydroxypropionic acidSereneL-3-Hydroxy-alaninebeta-Hydroxy-L-alanineL-2-Amino-3-hydroxypropionic acidL-3-Hydroxy-2-aminopropionic acidPropanoic acid, 2-amino-3-hydroxy-, (S)-3-Hydroxyalanine(S)-(-)-SerineCHEBI:17115(S)-alpha-Amino-beta-hydroxypropionic acid452VLY9402NSC-118365(S)-2-amino-3-hydroxy-Propanoic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17115
ChEMBL:CHEMBL11298
EPA DTXSID:DTXSID301031857
EPA DTXSID:DTXSID60883230
PubMed:40157434
PubMed:34170685
PubMed:32781134
PubMed:30476904
PubMed:29968805
PubMed:29098664
PubMed:28975502
PubMed:27387750
PubMed:23122394
PubMed:23118509
PubMed:23118497
PubMed:23115188

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SERINE

INCI name

SERINE

INN name

serine

Ph. Eur. name

serinum

Description

2-Amino-3-hydroxypropanoic acid

Record provenance

Inventory reference: 37660
Imported identity: SERINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for SERINE

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Key data

CAS

302-84-1 / 56-45-1

206-130-6 / 200-274-3

Restriction

—

Function

ANTISTATIC: Preventing and/or reducing static electricity by neutralising electrical charge on surfaces.
FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#25620 · SERINE

Ingredients with overlapping formulation functions

SAFFLOWERAMIDOPROPYL ETHYLDIMONIUM ETHOSULFATEANTISTATIC, HAIR CONDITIONING

SCIADOPITYS VERTICILLATA ROOT EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTISTATIC, SKIN CONDITIONING

SERICA POWDERANTISTATIC, BULKING, HAIR CONDITIONING, SKIN CONDITIONING, SMOOTHING

SERICINANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING, SMOOTHING

SESAMIDOPROPYL BETAINEANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - F…

SESAMIDOPROPYL DIMETHYLAMINEANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING

SHEABUTTERAMIDOPROPYL DIMETHYLAMINEANTISTATIC

SILICONE QUATERNIUM-1ANTISTATIC, HAIR CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SERINE appears in the CosIng inventory

The CosIng inventory lists SERINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SERINE is also tagged with 4 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SERINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SERINE carries the following function designation(s):

CAS 302-84-1 / 56-45-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for SERINE

This page reproduces the CosIng inventory entry for SERINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SERINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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