Is RUTIN safe to use in EU cosmetics?

RUTIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does RUTIN serve in cosmetics?

According to the EU CosIng inventory, RUTIN carries the following function designation(s): ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING.

How do I check if my formula contains RUTIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3756415/10/2010

RUTIN

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

RUTIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 153-18-4

CAS 153-18-4PubChem CID 5280805

Rutin

Rutin is a rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups. It has a role as an antioxidant and a metabolite. It is a rutinoside, a tetrahydroxyflavone, a disaccharide derivative and a quercetin O-glucoside. — ChEBI

IUPAC name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Molecular formula: C27H30O16
Molecular weight: 610.5 g/mol
Exact mass: 610.15338487 Da
XLogP3: -1.3
Topological polar surface area: 266.0 Å²
Hydrogen-bond donors: 10
Hydrogen-bond acceptors: 16
Covalent units: 1
Defined stereocentres: 10

Also known as

rutosideQuercetin 3-rutinosideBirutanPhytomelinSophorinIlixanthinMyrticolorinGlobulariacitrin

16 more reported names

OsyritrinPaliurosideTanrutin3-Rutinosyl quercetinQuercetin-3-rutinosideQuercetin 3-O-rutinosideYunxiangganRutosidoRutine3-RhamnoglucosylquercetinRutosidumRutinumquercetin-3-O-rutinosideNovarrutinaViolaquercetrinC.I. 75730

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28527
ChEMBL:CHEMBL226335
EPA DTXSID:DTXSID3022326
PubMed:40328339
PubMed:40154830
PubMed:39510200
PubMed:39239657
PubMed:39095945
PubMed:39053873
PubMed:39032614
PubMed:38555047
PubMed:38211767
PubMed:37184799
PubMed:37167442
PubMed:36966614

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for RUTIN

INCI name

RUTIN

INN name

rutoside

Ph. Eur. name

rutinum

Description

4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Record provenance

Inventory reference: 37564
Imported identity: RUTIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for RUTIN

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Key data

CAS

153-18-4 / 130603-71-4

205-814-1

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#24745 · RUTIN

Ingredients with overlapping formulation functions

RUBUS IDAEUS CALLUS EXTRACTANTIOXIDANT, SKIN PROTECTING

RUBUS IDAEUS JUICE VESICLESANTIOXIDANT; ANTI-SEBUM; SKIN PROTECTING

RUBUS IDAEUS/URSINUS FRUIT EXTRACTANTIOXIDANT

RUMEX CRISPUS WATERANTIOXIDANT; ASTRINGENT; HUMECTANT; SKIN CONDITIONING - HUMECTANT

RUTINYL SUCCINATEANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING, UV ABSORBER

S-ARACHIDONOYL/LINOLENOYL/LINOLEOYL GLUTATHIONEANTIOXIDANT

S-BLACK WIDOW SPIDER HEXAPEPTIDE-1 SPANTIOXIDANT, EYELASH CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

S-BLACK WIDOW SPIDER PENTAPEPTIDE-1 SPANTIOXIDANT, EYELASH CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How RUTIN appears in the CosIng inventory

The CosIng inventory lists RUTIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

RUTIN is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

RUTIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, RUTIN carries the following function designation(s):

CAS 153-18-4 / 130603-71-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for RUTIN

This page reproduces the CosIng inventory entry for RUTIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research RUTIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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