What does the restriction note for PHYTONADIONE mean?

The restriction field for PHYTONADIONE reads: II/1371. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

How do I check if my formula contains PHYTONADIONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3655615/10/2010

PHYTONADIONE

1,4-Naphthalenedione, 2-methyl[3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*, R*-(E)]]-; Vitamin K1

PHYTONADIONE is linked to 1 EU annex record on this page. Inventory note: II/1371.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited Open this evidence	2	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Evidence linked Prohibited Open this evidence	1	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Evidence linked Prohibited Open this evidence	1	Portuguese with INCI crosswalks
India	Evidence linked Prohibited Open this evidence	1	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 81818-54-4

CAS 81818-54-4PubChem CID 4812

2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecen-1-yl)-1,4-naphthoquinone

2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone has been reported in Brassica oleracea, Homo sapiens, and other organisms with data available. — LOTUS - the natural products occurrence database

IUPAC name: 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione

Molecular formula: C31H46O2
Molecular weight: 450.7 g/mol
Exact mass: 450.349780706 Da
XLogP3: 10.9
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

RefChem:2632272-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dioneEINECS 279-833-9Vitamin K1-d7ProkayvitoralPhytomenadione)C31H46O22-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone

13 more reported names

Vitamin K1 (Phytonadione Impurity 32Vitamin K1 Impurity 66Dry Vitamin K1 5% SDphylloquinone;2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONEMBWXNTAXLNYFJB-UHFFFAOYSA-NHMS3259K20HMS3372D04s4698Phytomenadione/Vitamin K1 Impurity 95Vitamin K1 (Phylloquinone) (E-Isomer)DB-0568231,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecen-1-yl)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL4549212
EPA DTXSID:DTXSID80859134
PubMed:22235314
PubMed:18799171
PubMed:16771431
PubMed:16566585
PubMed:12615349

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 84-80-0

CAS 84-80-0PubChem CID 5284607

Phylloquinone

Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a member of phylloquinones and a vitamin K. — ChEBI

IUPAC name: 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione

Molecular formula: C31H46O2
Molecular weight: 450.7 g/mol
Exact mass: 450.349780706 Da
XLogP3: 10.9
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 2

Also known as

VITAMIN K1phytonadionePhytomenadionePhytylmenadioneMephyton3-PhytylmenadioneMonodionSynthex P

16 more reported names

PhyllochinonKinadionKephtonMono-KayCombinal K1FitomenadionaKativ Nalpha-Phylloquinonetrans-PhylloquinoneK-Ject2-Methyl-3-phytyl-1,4-naphthoquinoneAntihemorrhagic vitaminPhyllochinonumPhytomenadionumPhytonadionumOrakay

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:18067
ChEMBL:CHEMBL1550
EPA DTXSID:DTXSID8023472
PubMed:38037266
PubMed:34520801
PubMed:31639794
PubMed:31173816
PubMed:29581108
PubMed:27412937
PubMed:27212383
PubMed:25747538
PubMed:23990204
PubMed:23769903
PubMed:23533172
PubMed:22417713

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PHYTONADIONE

INCI name

PHYTONADIONE

INN name

phytomenadione

Description

1,4-Naphthalenedione, 2-methyl[3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*, R*-(E)]]-; Vitamin K1

Record provenance

Inventory reference: 36556
Imported identity: PHYTONADIONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PHYTONADIONE

Annex II Restriction reference

Entry 1371

Phytonadione [INCI], phytomenadione [INN]

CAS: 84-80-0 -- 81818-54-4

EC: 201-564-2 -- 279-833-9

Key data

CAS

84-80-0 / 81818-54-4

201-564-2 / 279-833-9

Restriction

II/1371

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20899 · PHYTONADIONE

Ingredients with overlapping formulation functions

PHYTOECDYSTEROIDSSKIN CONDITIONING

PHYTOGLOBINSKIN CONDITIONING

PHYTOLACCA BOGOTENSIS LEAF EXTRACTHUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

PHYTOLACCA DECANDRA EXTRACTSKIN CONDITIONING

PHYTOSPHINGOSINEHAIR CONDITIONING, SKIN CONDITIONING

PHYTOSPHINGOSINE ACETAMIDEANTI-SEBORRHEIC, ANTIMICROBIAL, HAIR CONDITIONING, SKIN CONDITIONING

PHYTOSPHINGOSINE ASCORBATESKIN CONDITIONING

PHYTOSPHINGOSINE CYCLIC PHOSPHATE HCLHAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PHYTONADIONE appears in the CosIng inventory

The CosIng inventory lists PHYTONADIONE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHYTONADIONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHYTONADIONE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PHYTONADIONE reads: "II/1371". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PHYTONADIONE carries the following function designation(s):

SKIN CONDITIONING

CAS 84-80-0 / 81818-54-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PHYTONADIONE

This page combines the CosIng inventory entry for PHYTONADIONE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PHYTONADIONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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