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CAS 335-27-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3649015/10/2010

PERFLUORODIMETHYLCYCLOHEXANE

Cyclohexane, 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)-.

PERFLUORODIMETHYLCYCLOHEXANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 335-27-3

CAS 335-27-3PubChem CID 78975

Perfluoro(1,3-dimethylcyclohexane)

IUPAC name: 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane

Molecular formula: C8F16
Molecular weight: 400.06 g/mol
Exact mass: 399.9744506 Da
XLogP3: 5.4
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 16
Covalent units: 1
Defined stereocentres: 0

Also known as

PerfluorodimethylcyclohexaneDecafluoro-1,3-bis(trifluoromethyl)cyclohexaneCyclohexane, decafluoro-1,3-bis(trifluoromethyl)-Q1Y54IOL0PCyclohexane, perfluoro-1,3-dimethyl-Cyclohexane, 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)-FLUTEC PC3NSC 4782

16 more reported names

NSC-4782EINECS 206-386-9FLUTEC PC-3FIFLOW 100RefChem:860198Perfluoro1,3dimethylcyclohexaneCyclohexane, perfluoro1,3dimethylHexadecafluoro1,3dimethylcyclohexanePERFLUORODIMETHYLCYCLOHEXANE [INCI]Decafluoro1,3bis(trifluoromethyl)cyclohexaneCyclohexane, decafluoro1,3bis(trifluoromethyl)1,1,2,2,3,3,4,5,5,6Decafluoro4,6bis(trifluoromethyl)cyclohexaneCyclohexane, 1,1,2,2,3,3,4,5,5,6decafluoro4,6bis(trifluoromethyl)Perfluoro-1,3-dimethylcyclohexaneHexadecafluoro(1,3-dimethylcyclohexane)Perfluoro-1,3-dimethylcyclohexane,

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID0036926
PubMed:21928010
PubMed:21594285
PubMed:18461988
PubMed:15549788
PubMed:12017469
PubMed:11746900

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PERFLUORODIMETHYLCYCLOHEXANE

INCI name

PERFLUORODIMETHYLCYCLOHEXANE

Description

Cyclohexane, 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)-.

Record provenance

Inventory reference: 36490
Imported identity: PERFLUORODIMETHYLCYCLOHEXANE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PERFLUORODIMETHYLCYCLOHEXANE

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Key data

CAS

335-27-3

206-386-9

Restriction

—

Function

SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20466 · PERFLUORODIMETHYLCYCLOHEXANE

Ingredients with overlapping formulation functions

PENTANONESOLVENT

PENTYLENE GLYCOLSKIN CONDITIONING, SOLVENT

PERFLUOROCAPRYLYL BROMIDESOLVENT

PERFLUORODECALINDETANGLING, SKIN CONDITIONING, SOLVENT

PERFLUOROHEXANESOLVENT

PERFLUOROMETHYLCYCLOPENTANESKIN CONDITIONING, SOLVENT

PERFLUOROPERHYDROBENZYL TETRALINSKIN CONDITIONING, SOLVENT

PERFLUOROPERHYDROPHENANTHRENESKIN CONDITIONING, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PERFLUORODIMETHYLCYCLOHEXANE appears in the CosIng inventory

The CosIng inventory lists PERFLUORODIMETHYLCYCLOHEXANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PERFLUORODIMETHYLCYCLOHEXANE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PERFLUORODIMETHYLCYCLOHEXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PERFLUORODIMETHYLCYCLOHEXANE carries the following function designation(s):

SOLVENT

CAS 335-27-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PERFLUORODIMETHYLCYCLOHEXANE

This page reproduces the CosIng inventory entry for PERFLUORODIMETHYLCYCLOHEXANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PERFLUORODIMETHYLCYCLOHEXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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