Is NORVALINE safe to use in EU cosmetics?

NORVALINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains NORVALINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

Norvaline — Antistatic | CosIng Checker

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 2013-12-9

CAS 2013-12-9PubChem CID 439575

D-Norvaline

D-2-aminopentanoic acid is a 2-aminopentanoic acid that has R-configuration. It has a role as an EC 6.1.1.4 (leucine--tRNA ligase) inhibitor. It is a D-alpha-amino acid and a 2-aminopentanoic acid. It is an enantiomer of a L-2-aminopentanoic acid. — ChEBI

IUPAC name: (2R)-2-aminopentanoic acid

Molecular formula: C5H11NO2
Molecular weight: 117.15 g/mol
Exact mass: 117.078978594 Da
XLogP3: -2.1
Topological polar surface area: 63.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

D-2-Aminopentanoic acidD-2-Aminovaleric acid(R)-norvalineNorvaline, D-102E6YF9W5CHEBI:28804RefChem:1082915217-936-2

16 more reported names

D(-)-NorvalineH-D-Nva-OH(R)-2-AMINOPENTANOIC ACIDD-(-)-Norvaline(2R)-2-azaniumylpentanoateD-Norvaline, 99%alpha -DL-Aminopentanoic acidNorvaline (ACD/Name 4.0)UNII-102E6YF9W5(R)-(-)-2-Aminopentanoic acidAS-12608HY-41309CS-0015963(R)-2-Aminovaleric Acid(.+-.)-NorvalineD-Ape

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28804
ChEMBL:CHEMBL1916081
EPA DTXSID:DTXSID40942157
PubMed:22050382
PubMed:19498234
PubMed:18172831
PubMed:15358424

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6600-40-4

CAS 6600-40-4PubChem CID 65098

L-Norvaline

L-2-aminopentanoic acid is a 2-aminopentanoic acid that has S-configuration. It has a role as a hypoglycemic agent, a neuroprotective agent and a bacterial metabolite. It is an enantiomer of a D-2-aminopentanoic acid. It is a tautomer of a L-2-aminopentanoic acid zwitterion. — ChEBI

IUPAC name: (2S)-2-aminopentanoic acid

Molecular formula: C5H11NO2
Molecular weight: 117.15 g/mol
Exact mass: 117.078978594 Da
XLogP3: -2.1
Topological polar surface area: 63.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

norvaline(S)-2-Aminopentanoic acidL-2-Aminovaleric acidL-2-aminopentanoic acidA70UKS48FECHEBI:18314NSC-203786alpha-Aminovaleric acid

16 more reported names

RefChem:854766(2S)-2-azaniumylpentanoate229-543-3h-nva-ohL-2-aminopentanoate(S)-2-Aminovaleric acidNorvaline, L-Norvaline (VAN)Pentanoic acid, 2-amino-L(+)-Norvaline2S-amino-pentanoic acidPentanoic acid, 2-amino-, (S)-EINECS 229-543-3Valeric acid, 2-amino-HY-Y0399NVA

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:18314
ChEMBL:CHEMBL55612
EPA DTXSID:DTXSID701018015
PubMed:22679369
PubMed:22363663
PubMed:22248298
PubMed:22145465
PubMed:21747978
PubMed:21269440
PubMed:20526857
PubMed:20512454
PubMed:19756721
PubMed:19489061
PubMed:19284655
PubMed:19248796

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 760-78-1

CAS 760-78-1PubChem CID 824

DL-norvaline

2-aminopentanoic acid is an alpha-amino acid that is valeric acid which is substituted at position 2 by an amino group. It is functionally related to a valeric acid. — ChEBI

IUPAC name: 2-aminopentanoic acid

Molecular formula: C5H11NO2
Molecular weight: 117.15 g/mol
Exact mass: 117.078978594 Da
XLogP3: -2.1
Topological polar surface area: 63.3 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Aminovaleric acidNorvaline, DL-(+-)-NorvalineDL-2-Aminovaleric AcidNSC 7904V639KTF2SZalpha-aminopentanoic acidNSC-7904

16 more reported names

EINECS 212-082-7norvalinesAI3-18299CHEBI:194752-aminovalerate2-aminopentanoate2-aminovalerianic acidalpha-amino-N-valeratealpha-amino-N-valeric acid2-azaniumylpentanoateDL2Aminopentanoic acidDLalphaAminovaleric acidRefChem:589970alphaDLAminopentanoic acidValeric acid, 2amino, DL212-082-7

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:19475
EPA DTXSID:DTXSID00862403
PubMed:23088911
PubMed:22867532
PubMed:22679369
PubMed:22654866
PubMed:22648413
PubMed:22629087
PubMed:22431978
PubMed:22325018
PubMed:22295078
PubMed:22291884
PubMed:22281732
PubMed:22187559

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NORVALINE

INCI name

NORVALINE

Description

2-Aminopentanoic acid

Record provenance

Inventory reference: 35560
Imported identity: NORVALINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NORVALINE

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Key data

CAS

2013-12-9 / 6600-40-4 / 760-78-1

EC

217-936-2 / 229-543-3 / 212-082-7

Restriction

—

Function

ANTISTATIC: Preventing and/or reducing static electricity by neutralising electrical charge on surfaces.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17617 · NORVALINE

Ingredients with overlapping formulation functions

MYRISTYL BETAINEANTISTATIC, CLEANSING, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - F…

MYRISTYL HYDROXYETHYL IMIDAZOLINEANTISTATIC, HAIR CONDITIONING

NELUMBO NUCIFERA STAMEN EXTRACTANTISTATIC, SKIN PROTECTING

NIACINANTISTATIC, SMOOTHING

OATAMIDOPROPYL DIMETHYLAMINEANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

OCTACOSATRIMONIUM CHLORIDEANTISTATIC, HAIR CONDITIONING

OCTYL POLYSTYRENE OXIDE/PEG-10 COPOLYMERANTISTATIC, CHELATING

OCTYLACRYLAMIDE/ACRYLATES/BUTYLAMINOETHYL METHACRYLATE COPOLYMERANTISTATIC, FILM FORMING, HAIR FIXING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NORVALINE appears in the CosIng inventory

The CosIng inventory lists NORVALINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NORVALINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NORVALINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NORVALINE carries the following function designation(s):

ANTISTATIC

CAS 2013-12-9 / 6600-40-4 / 760-78-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for NORVALINE

This page reproduces the CosIng inventory entry for NORVALINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NORVALINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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NORVALINE

Regulatory evidence by market

Chemical identity and properties

D-Norvaline

L-Norvaline

DL-norvaline

Inventory details for NORVALINE

INCI name

Description

Record provenance

Annex records for NORVALINE

Browse EU annexes

Search annex entries

Key data

Official EU ingredient-name evidence

Ingredients with overlapping formulation functions

Additional official and scientific sources

How NORVALINE appears in the CosIng inventory

Frequently asked questions

Source note for NORVALINE

Tools & next steps

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Regulatory evidence by market

Chemical identity and properties

D-Norvaline

L-Norvaline

DL-norvaline

Inventory details for NORVALINE

INCI name

Description

Record provenance

Annex records for NORVALINE

Browse EU annexes

Search annex entries

Key data

Official EU ingredient-name evidence

Related inventory evidence

Ingredients with overlapping formulation functions

Additional official and scientific sources

How NORVALINE appears in the CosIng inventory

Frequently asked questions

Is NORVALINE safe to use in EU cosmetics?

What function does NORVALINE serve in cosmetics?

What other records share CAS number 2013-12-9 / 6600-40-4 / 760-78-1?

How do I check if my formula contains NORVALINE?

Source note for NORVALINE

Tools & next steps

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