METHYLENE DI-T-BUTYLCRESOL
6,6'-Di-tert-Butyl-2,2'-Methylenedi-p-cresol
METHYLENE DI-T-BUTYLCRESOL is linked to 1 EU annex record on this page.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Evidence linked Prohibited entry found Open this evidence | 1 | English and EU languages |
| Great Britain | Evidence linked Prohibited Open this evidence | 1 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Evidence linked Prohibited Open this evidence | 1 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Source mapped Official source mapped; ingredient rule not imported | 0 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Evidence linked Prohibited Open this evidence | 1 | Arabic and English |
Chemical identity and properties
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is a diarylmethane. — ChEBI
- IUPAC name
- 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
- Molecular formula
- C23H32O2
- Molecular weight
- 340.5 g/mol
- Exact mass
- 340.240230259 Da
- XLogP3
- 7.2
- Topological polar surface area
- 40.5 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:172336
- ChEMBL:CHEMBL460648
- EPA DTXSID:DTXSID4020870
- PubMed:40228673
- PubMed:38160208
- PubMed:33352258
- PubMed:22796571
- PubMed:16749692
- PubMed:16497524
- PubMed:16238337
- PubMed:16231125
- PubMed:15811949
- PubMed:15252483
- PubMed:12816477
- PubMed:11266322
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: Off-white powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.07-1.10 kg/L Source: Hazardous Substances Data Bank (HSDB)
- LogP: Log Kow = 6.25 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 118-128 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Liquid; Dry Powder; Other Solid; Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Off-white solid; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Soluble in oxygen and aromatic solvents. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Water solubility = 0.02 mg/l. Source: Hazardous Substances Data Bank (HSDB)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H360F: May damage fertility [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for 15.4% (153 of 995) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H360F (25.2%): May damage fertility [Danger Reproductive toxicity]; H361 (46.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H413 (47.4%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P273, P280, P318, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 995 reports by companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 153 of 995 reports by companies.; There are 32 notifications provided by 842 of 995 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
- Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- Environmental Bioconcentration: An estimated BCF value of 33100 was calculated for bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane(SRC), using an experimental log Kow of 6.25(1) and a recommended regression-derived equation(2). Bioconcentration factors of 23-37 and 60-125 were obtained during an 8 week bioconcentration study using carp and bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane concentrations of 1 and 0.1 mg/l, respectively(1). According to a recommended classification scheme(3), the experimental BCF values suggest that bioconcentration in aquatic organisms will be moderate to high(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 59800(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will have no mobility in soil(SRC). Volatilization of bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane may not be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 7.9X10-12 atm-cu m/mole(4,SRC), or from dry soil surfaces(SRC) based on an estimated vapor pressure of 2.5X10-9 mm Hg(5,SRC). Based on a MITI biodegradation test, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will not biodegrade in soil(2). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 59800(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will adsorb to suspended solids and sediment(SRC) in the water. Bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane should not volatilize from water surfaces based on an estimated Henry's Law constant of 7.9X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Experimental BCF values of 23-37 and 60-125 at 1 and 0.1 mg/L(2), suggest that bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(5). Based on a MITI biodegradation test, bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will not biodegrade in water(2). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a suggested classification scheme(1), an estimated vapor pressure of 2.5X10-9 mm Hg at 25 °C(2,SRC) indicates that bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane will exist in the particulate phase in the ambient atmosphere. Particulate-phase bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane may be physically removed from the air by wet and dry deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Antioxidant Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable; UV stabilizer; Processing aids not otherwise specified; Antioxidant Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as an antioxidant and stabilizer for polymers (ABS, polypropylene, polyacetal, rubber, latex, and adhesives); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Stabilizer used in styrenic and olefin polymers and polyoxymethylene homo and copolymers. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Antioxidant (ABS, polypropylene, polyacetal, rubber, latex, adhesives). Source: Hazardous Substances Data Bank (HSDB)
- Uses: Plastics -> Typical concentration range in plastic materials -> 0.5% Source: NORMAN Suspect List Exchange
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for METHYLENE DI-T-BUTYLCRESOL
INCI name
METHYLENE DI-T-BUTYLCRESOL
Description
6,6'-Di-tert-Butyl-2,2'-Methylenedi-p-cresol
Record provenance
- Inventory reference
- 35336
- Imported identity
- METHYLENE DI-T-BUTYLCRESOL
- Source update
- 15/10/2010
Annex records for METHYLENE DI-T-BUTYLCRESOL
6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol;[DBMC]
Key data
- ANTIOXIDANT
- Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How METHYLENE DI-T-BUTYLCRESOL appears in the CosIng inventory
The CosIng inventory lists METHYLENE DI-T-BUTYLCRESOL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.
METHYLENE DI-T-BUTYLCRESOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for METHYLENE DI-T-BUTYLCRESOL
This page combines the CosIng inventory entry for METHYLENE DI-T-BUTYLCRESOL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.
Use this inventory page to research METHYLENE DI-T-BUTYLCRESOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
Check your formula
Scan a full INCI list to detect METHYLENE DI-T-BUTYLCRESOL and any linked EU annex restrictions or allergen flags.
INCI CheckerSearch similar ingredients
Find other inventory ingredients and annex entries related to METHYLENE DI-T-BUTYLCRESOL, its identifiers or nearby name variants.
Search