Is MENTHYL PCA safe to use in EU cosmetics?

MENTHYL PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains MENTHYL PCA?

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InventoryRef 3523415/10/2010

MENTHYL PCA

[1R-(1.alpha.,2.beta.,5.alpha.)]-2-Isopropyl-5-methylcyclohexyl 5-oxo-L-prolinate / [1R-(1.alpha.,2.beta.,5.alpha.)]-2-Isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate

MENTHYL PCA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 64519-44-4

CAS 64519-44-4PubChem CID 115834

L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

IUPAC name: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate

Molecular formula: C15H25NO3
Molecular weight: 267.36 g/mol
Exact mass: 267.18344366 Da
XLogP3: 3.0
Topological polar surface area: 55.4 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 4

Also known as

UNII-C7ZIB25BE7C7ZIB25BE7(-)-Menthyl (-)-2-pyrrolidone-5-carboxylateEINECS 264-935-8(-)Menthyl 2-pyrrolidone-5-carboxylateMenthyl pyrrolidone carboxylate, (-),L-(-)-MENTHYL L-PIDOLATE(-)Menthyl (-)-2-pyrrolidone-5-carboxylate

16 more reported names

(-)-MENTHYL L-PYROGLUTAMATEMENTHYL PYROGLUTAMATE, (-),L-(-)-MENTHYL L-PYRROLIDONE CARBOXYLATEMENTHYL PYRROLIDONE CARBOXYLATE, (-)-MENTHYL PYRROLIDONE CARBOXYLATE, L-(-)-((1R,2S,5R)-2-ISOPROPYL-5-METHYL-CYCLOHEXYL) (2S)-5-OXOPYRROLIDINE-2-CARBOXYLATEL-PROLINE, 5-OXO-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylateRefChem:151937FEMA NO. 4155, (-),L-264-935-8L-PROLINE, 5-OXO-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1ALPHA,2BETA,5ALPHA))-(1R,2S,5R)-5-Methyl-2-isopropylcyclohexyl 5-oxo-L-prolinate(S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-oxopyrrolidine-2-carboxylate(1R, 2S, 5R)-5-Methyl-2-isopropylcyclohexyl-5-oxo-L-prolinate(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (S)-5-oxopyrrolidine-2-carboxylate

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External database identifiers

EPA DTXSID:DTXSID80886687

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 68127-22-0

CAS 68127-22-0PubChem CID 21118466

Menthyl pyrrolidone carboxylate, D-(-)-

IUPAC name: [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2R)-5-oxopyrrolidine-2-carboxylate

Molecular formula: C15H25NO3
Molecular weight: 267.36 g/mol
Exact mass: 267.18344366 Da
XLogP3: 3.0
Topological polar surface area: 55.4 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 4

Also known as

Y27B4585KOD-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl esterRefChem:810982FEMA NO. 4155, (-),D-5-Oxo-D-proline (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(-)-Menthyl (+)-2-pyrrolidone-5-carboxylate(1R,2S,5R)-Menthyl (R)-PyroglutamateUNII-Y27B4585KO

8 more reported names

EINECS 268-568-4Menthyl pyrrolidone carboxylate, (-),D-SLHPMAOXNSLXEH-YVECIDJPSA-ND-(-)-menthyl pyrrolidone carboxylate(1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 5-oxo-D-prolinate((1R,2S,5R)-2-ISOPROPYL-5-METHYL-CYCLOHEXYL) (2R)-5-OXOPYRROLIDINE-2-CARBOXYLATE(1R-(1alpha,2beta,5alpha))-2-Isopropyl-5-methylcyclohexyl 5-oxo-D-prolinateD-PROLINE, 5-OXO-, 5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL ESTER, (1R-(1.ALPHA.,2.BETA.,5.ALPHA.))-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID10887167

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MENTHYL PCA

INCI name

MENTHYL PCA

Description

[1R-(1.alpha.,2.beta.,5.alpha.)]-2-Isopropyl-5-methylcyclohexyl 5-oxo-L-prolinate / [1R-(1.alpha.,2.beta.,5.alpha.)]-2-Isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate

Record provenance

Inventory reference: 35234
Imported identity: MENTHYL PCA
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MENTHYL PCA

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Key data

CAS

64519-44-4 / 68127-22-0

264-935-8 / 268-568-4

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16254 · MENTHYL PCA

Ingredients with overlapping formulation functions

MELIBIOSEHUMECTANT

MENTHA ARVENSIS BRANCH/LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

MENTHA CANADENSIS BRANCH/LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

MENTHYL NICOTINATEHUMECTANT

MESEMBRYANTHEMUM CRYSTALLINUM CALLUS EXTRACTHUMECTANT, SKIN CONDITIONING

MESEMBRYANTHEMUM CRYSTALLINUM EXTRACTHUMECTANT

MESEMBRYANTHEMUM CRYSTALLINUM JUICEHUMECTANT, SKIN CONDITIONING

METHOXY PEG-10HUMECTANT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MENTHYL PCA appears in the CosIng inventory

The CosIng inventory lists MENTHYL PCA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MENTHYL PCA is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MENTHYL PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MENTHYL PCA carries the following function designation(s):

CAS 64519-44-4 / 68127-22-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for MENTHYL PCA

This page reproduces the CosIng inventory entry for MENTHYL PCA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MENTHYL PCA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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