Is MANNITOL safe to use in EU cosmetics?

MANNITOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What function does MANNITOL serve in cosmetics?

According to the EU CosIng inventory, MANNITOL carries the following function designation(s): BINDING, FRAGRANCE, HUMECTANT, MOISTURISING, SKIN CONDITIONING.

What other records share CAS 69-65-8?

CAS 69-65-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains MANNITOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3516715/10/2010

MANNITOL

D-Mannitol

MANNITOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 69-65-8

CAS 69-65-8PubChem CID 6251

Mannitol

D-mannitol is the D-enantiomer of mannitol. It has a role as a member of compatible osmolytes, a metabolite, an antiglaucoma drug, an osmotic diuretic, a sweetening agent, an allergen, a hapten, an Escherichia coli metabolite, a food anticaking agent, a food stabiliser, a food humectant, a food thickening agent and a food bulking agent. — ChEBI

IUPAC name: (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol

Molecular formula: C6H14O6
Molecular weight: 182.17 g/mol
Exact mass: 182.07903816 Da
XLogP3: -3.1
Topological polar surface area: 121.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 4

Also known as

D-mannitolManniteOsmitrolManna sugarCordycepic acidDiosmolResectisolMannidex

16 more reported names

MannigenOsmosalMannitD-(-)-MannitolMannazuckerMannistolInvenexIsotolMannitol, D-Marine CrystalManiton-SMannogem 2080Bronchitol(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaolMannitol 5%Aridol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16899
ChEMBL:CHEMBL689
EPA DTXSID:DTXSID1023235
EPA DTXSID:DTXSID30858955
PubMed:37992803
PubMed:30864794
PubMed:29968805
PubMed:29803612
PubMed:25270620
PubMed:24778426
PubMed:23867654
PubMed:23816505
PubMed:23143036
PubMed:23123464
PubMed:23112534
PubMed:23106006

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MANNITOL

INCI name

MANNITOL

INN name

mannitol

Ph. Eur. name

mannitolum

Description

D-Mannitol

Record provenance

Inventory reference: 35167
Imported identity: MANNITOL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MANNITOL

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Key data

CAS

69-65-8

200-711-8

Restriction

—

Function

BINDING: Providing adhesive properties during and after compression in cosmetic tablets and/or cakes.
FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
HUMECTANT: Retaining and/or preserving the moisture in a product during use.
MOISTURISING: Increasing the water content of the skin and keeping it soft and smooth.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16004 · MANNITOL

Ingredients with overlapping formulation functions

MAGNESIUM STEARATEANTICAKING, BULKING, COLORANT, MOISTURISING

MALTITOLFRAGRANCE, HUMECTANT, MOISTURISING, SKIN CONDITIONING

MALTOSEFRAGRANCE, MOISTURISING, SKIN CONDITIONING

MANGANESE PCAHUMECTANT, MOISTURISING, SKIN CONDITIONING

MELHUMECTANT, MOISTURISING, SKIN CONDITIONING - EMOLLIENT

MEL EXTRACTMOISTURISING

METHYL GLUCETH-10HUMECTANT, MOISTURISING, SURFACTANT - EMULSIFYING

METHYL GLUCETH-20HUMECTANT, MOISTURISING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MANNITOL appears in the CosIng inventory

The CosIng inventory lists MANNITOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MANNITOL is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MANNITOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MANNITOL carries the following function designation(s):

CAS 69-65-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for MANNITOL

This page reproduces the CosIng inventory entry for MANNITOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MANNITOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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