Is HESPERIDIN safe to use in EU cosmetics?

HESPERIDIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 520-26-3?

CAS 520-26-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains HESPERIDIN?

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InventoryRef 3425215/10/2010

HESPERIDIN

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-

HESPERIDIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 520-26-3

CAS 520-26-3PubChem CID 10621

Hesperidin

Hesperidin is a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a mutagen. It is a member of 4'-methoxyflavanones, a rutinoside, a monomethoxyflavanone, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a disaccharide derivative and a flavanone glycoside. It is functionally related to a hesperetin. — ChEBI

IUPAC name: (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one

Molecular formula: C28H34O15
Molecular weight: 610.6 g/mol
Exact mass: 610.18977037 Da
XLogP3: -1.1
Topological polar surface area: 234.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 15
Covalent units: 1
Defined stereocentres: 11

Also known as

CirantinHesperidosideHesperetin 7-rutinosideCiratin(S)-(-)-HesperidinDIOSVEINHesperetin 7-rhamnoglucosideCHEBI:28775

16 more reported names

E750O06Y6OHesperetin 7 RhamnoglucosideHesperetin 7-O-rutinosideNSC-441844H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyl)oxy)-4-chromanonHesperidin 2S2S, HesperidinHesperetin GlycosideRefChem:5881Hesperetin 7 Rutinoside7-Rhamnoglucoside, HesperetinNDI 590208-288-1NSC-31048(s)-7-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28775
ChEMBL:CHEMBL449317
EPA DTXSID:DTXSID9044328
PubMed:11509977
PubMed:8825617
PubMed:8158164
PubMed:4789552
PubMed:1695572

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HESPERIDIN

INCI name

HESPERIDIN

Description

4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-

Record provenance

Inventory reference: 34252
Imported identity: HESPERIDIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for HESPERIDIN

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Key data

CAS

520-26-3

208-288-1

Restriction

—

Function

SKIN CONDITIONING - EMOLLIENT: Acting as lubricants on the skin surface providing the skin with a soft and smooth appearance.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11821 · HESPERIDIN

Ingredients with overlapping formulation functions

HEPTYL UNDECYLENATESKIN CONDITIONING - EMOLLIENT

HEPTYLGLYCERINANTIMICROBIAL, ANTIPERSPIRANT, DEODORANT, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIE…

HEPTYLUNDECANOLSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

HEPTYLUNDECYL HYDROXYSTEARATESKIN CONDITIONING - EMOLLIENT

HESPERIDIN LAURATEANTI-SEBORRHEIC; ANTIMICROBIAL; ANTIOXIDANT; ANTI-SEBUM; SKIN CONDITIONING - EMOLLIENT

HEVEA BRASILIENSIS SEED OILSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

HEXADECENOIC ACIDSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

HEXADECENYL OLEYLSUCCINAMIDEBLEACHING, HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How HESPERIDIN appears in the CosIng inventory

The CosIng inventory lists HESPERIDIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HESPERIDIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HESPERIDIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HESPERIDIN carries the following function designation(s):

SKIN CONDITIONING - EMOLLIENT

CAS 520-26-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for HESPERIDIN

This page reproduces the CosIng inventory entry for HESPERIDIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HESPERIDIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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