InventoryRef 3384721/11/2016
ETHYL PHENYLACETATE
Ethyl phenylacetate
ETHYL PHENYLACETATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
- IUPAC name
- ethyl 2-phenylacetate
- Molecular formula
- C10H12O2
- Molecular weight
- 164.20 g/mol
- Exact mass
- 164.083729621 Da
- XLogP3
- 2.3
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Benzeneacetic acid, ethyl esterEthyl phenacetateEthyl 2-phenylethanoateEthyl benzeneacetateEthyl phenylethanoatePhenylacetic acid, ethyl esterEthyl alpha-toluateAcetic acid, phenyl-, ethyl ester
16 more reported names
FEMA No. 2452alpha-Toluic acid, ethyl esterNSC 406259V6CNZ04D8ONSC-8894NSC-406259EPhA esterRefChem:5814202-993-8Phenylacetic acid ethyl esterEthyl .alpha.-toluatePhenyl-acetic acid ethyl esterPhenyl-acetic acid, ethyl ester.alpha.-Toluic acid, ethyl esterPHENYL-ACETIC ACID,ETHYL ESTERWLN: 2OV1R
External database identifiers
- ChEBI:CHEBI:180411
- ChEMBL:CHEMBL3183476
- EPA DTXSID:DTXSID6044353
- PubMed:21483720
- PubMed:21348497
- PubMed:21313821
- PubMed:20532090
- PubMed:20336208
- PubMed:20065117
- PubMed:18990252
- PubMed:18570373
- PubMed:18045579
- PubMed:17924643
- PubMed:17530858
- PubMed:17163560
Evidence from additional scientific databases
EMBL-EBI ChEBI
Exact identifier matchCHEBI:180411
Ethyl phenylacetate
- Formula
- C10H12O2
- Average mass
- 164.204 g/mol
- Monoisotopic mass
- 164.08373 Da
- Formal charge
- 0
- benzenes — is a (CHEBI:22712)
- benzenes — is a (CHEBI:22712)
Additional curated names
ethyl 2-phenylacetate
Cross-references from this source
- CAS: 101-97-3 — ChemIDplus
- MANUAL_X_REF: 13885245 — ChemSpider
- MANUAL_X_REF: HMDB0032618 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Exact identifier match7590
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 228 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 227.00 to 229.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 228 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: Liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.0333 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.027-1.032 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Flash Point: 210 °F (99 °F) Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow = 2.28 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 2.28 Source: Human Metabolome Database (HMDB)
- Melting Point: -29.4 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -29.4 °C Source: Human Metabolome Database (HMDB)
- Odor: Sweet, honey odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Pleasant odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Liquid with a pleasant odor; [Merck Index] Clear colorless liquid; [Sigma-Aldrich MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: Colourless or nearly colourless liquid; pleasant sweet odour suggestive of honey Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.4980 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.494-1.500 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: In water, 1,478 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Very soluble in ethyl ether, ethanol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in fixed oils; insol in glycerin, propylene glycol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in 8 parts of 60% alcohol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Insoluble in water glyceryl, propylene glycol; soluble in oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 1 mL in 3 mL 70% ethanol (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 0.06 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Note: This chemical does not meet GHS hazard criteria for 99.8% (1778 of 1782) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 1778 of 1782 companies (only 0.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1782 reports by companies from 4 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 1778 of 1782 reports by companies.; There are 3 notifications provided by 4 of 1782 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Toxicity Summary: IDENTIFICATION AND USE: Ethyl phenyl acetate is a colorless liquid and a flavor ingredient found in food and drinks such as juices and wines. HUMAN STUDIES: In a human patch pretest, no skin irritation was found. There were no instances of contact-sensitization in healthy male volunteers. It was negative in the in vitro study performed to assess the irritation potential in the Human Skin Model Test. ANIMAL STUDIES: Ethyl phenyl acetate was not irritating to the eyes of rabbits. It was not sensitizing in guinea pigs. In a mutagenesis study with the Salmonella strains TA92, TA1535, TA100, TA1537, TA94, TA98 and for some samples TA2637 with and without metabolic activation no mutagenic effects were observed. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 15 was calculated in fish for ethyl phenylacetate(SRC), using a log Kow of 2.28(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 78, 110, and 129(2-4) indicate that ethyl phenylacetate is expected to have high mobility in soil(SRC). Volatilization of ethyl phenylacetate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.88X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Ethyl phenylacetate has an estimated vapor pressure of 6.24X10-2 mm Hg(SRC), determined from a fragment constant method(6) and exists as a liquid under environmental conditions; therefore, ethyl phenylacetate may volatilize from dry soil. Utilizing the Closed Bottle test, 78% degradation was reached in 28 days(7) indicating that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 78, 110, and 129(2-4) indicate that ethyl phenylacetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(5) based upon an estimated Henry's Law constant of 1.88X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(6). Using this Henry's Law constant and an estimation method(7), volatilization half-lives for a model river and model lake are 1.7 days and 23 days, respectively(SRC). According to a classification scheme(8), an estimated BCF of 15(SRC), from its log Kow of 2.28(9) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Utilizing the Closed Bottle test, 78% degradation was reached in 28 days(10) indicating that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl phenylacetate, which has an estimated vapor pressure of 6.24X10-2 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl phenylacetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 6.2 days(SRC), calculated from its rate constant of 5.2X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Ethyl phenylacetate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used to make perfumes; [Merck Index] Used as a flavoring agent; [FDA] Used to flavor animal feeds; [ExPub: EFSA - FEEDAP] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Farming (Feed Additives) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Table: Reported uses (ppm): (Flavor and Extract Manufacturers' Association, 1994) [Table#8420] Source: Hazardous Substances Data Bank (HSDB)
- Uses: Perfumery; flavors; intermediate, especially for phenobarbital; herbicide. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Food additive permitted for direct addition to food for human consumption. Synthetic flavoring substance and adjuvant. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Ethyl phenylacetate is a less toxic, greener solvent. It is non-mutagenic and is a certified Kosher food additive. Ethyl phenylacetate is used in perfumery. Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for Ethyl phenylacetate (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for ETHYL PHENYLACETATE
INCI name
ETHYL PHENYLACETATE
Description
Ethyl phenylacetate
Record provenance
- Inventory reference
- 33847
- Imported identity
- ETHYL PHENYLACETATE
- Source update
- 21/11/2016
Annex records for ETHYL PHENYLACETATE
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How ETHYL PHENYLACETATE appears in the CosIng inventory
The CosIng inventory lists ETHYL PHENYLACETATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
ETHYL PHENYLACETATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
ETHYL PHENYLACETATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, ETHYL PHENYLACETATE carries the following function designation(s):
CAS 101-97-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for ETHYL PHENYLACETATE
This page reproduces the CosIng inventory entry for ETHYL PHENYLACETATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research ETHYL PHENYLACETATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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