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CAS 1166-52-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3372815/10/2010

DODECYL GALLATE

Dodecyl 3,4,5-trihydroxybenzoate

DODECYL GALLATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1166-52-5

CAS 1166-52-5PubChem CID 14425

Dodecyl Gallate

Dodecyl gallate is a gallate ester. — ChEBI

IUPAC name: dodecyl 3,4,5-trihydroxybenzoate

Molecular formula: C19H30O5
Molecular weight: 338.4 g/mol
Exact mass: 338.20932405 Da
XLogP3: 5.8
Topological polar surface area: 87.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

Lauryl gallateNipagallin LAProgallin LAGallic acid, dodecyl esterBENZOIC ACID, 3,4,5-TRIHYDROXY-, DODECYL ESTERGallic acid, lauryl esterantioxidant E 312antioxidant E-312

16 more reported names

E 312 antioxidantE-312 antioxidantLauryl 3,4,5-trihydroxybenzoateDodecylester kyseliny galloveE3123,4,5-Trihydroxybenzoic acid, dodecyl esterNSC-133463INS NO.312INS-312E-312RefChem:135496214-620-6n-Dodecyl gallaten-dodecylgallateGALLIC ACID LAURYL ESTERNSC 133463

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:175304
ChEMBL:CHEMBL16121
EPA DTXSID:DTXSID0048189
PubMed:40651752
PubMed:33352258
PubMed:27965148
PubMed:26795242
PubMed:23063794
PubMed:22440576
PubMed:22285570
PubMed:21949409
PubMed:21856409
PubMed:21601026
PubMed:21194930
PubMed:21050744

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match14425

Attributed physical-property, hazard, environmental and use annotations.

Melting Point: Between 95 °C and 98 °C after drying at 90 °C for six hours Source: EU Food Improvement Agents
Melting Point: 96 - 97 °C Source: Human Metabolome Database (HMDB)

Physical Description: White or creamy-white odourless solid Source: EU Food Improvement Agents
Physical Description: Solid Source: Human Metabolome Database (HMDB)

Solubility: Insoluble in water, freely soluble in ethanol and ether Source: EU Food Improvement Agents

Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 68 reports by companies from 3 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Cosmetic Ingredient Review Link: CIR ingredient: Dodecyl Gallate Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DODECYL GALLATE

INCI name

DODECYL GALLATE

Ph. Eur. name

dodecylis gallas

Description

Dodecyl 3,4,5-trihydroxybenzoate

Record provenance

Inventory reference: 33728
Imported identity: DODECYL GALLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for DODECYL GALLATE

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Key data

CAS

1166-52-5

214-620-6

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9583 · DODECYL GALLATE

Ingredients with overlapping formulation functions

DITOCOPHERYL OXALATEANTIOXIDANT; SKIN CONDITIONING - MISCELLANEOUS; SKIN CONDITIONING - OCCLUSIVE

DITRIDECYL THIODIPROPIONATEANTIOXIDANT

DITYLUM BRIGHTWELLII EXTRACTANTIOXIDANT

DOCOSYLOXYMETHOXYBENZYL AZAFULLERENEDIONEANTIOXIDANT

DRABA ALPINA CALLUS CULTURE EXTRACTANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, SKIN PROTECTING

DRABA NEMOROSA EXTRACTANTIOXIDANT, SKIN CONDITIONING

DRACAENA STUCKYI WATERANTIOXIDANT

DRACOCEPHALUM MOLDAVICA FLOWER/LEAF/STEM WATERANTIOXIDANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DODECYL GALLATE appears in the CosIng inventory

The CosIng inventory lists DODECYL GALLATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DODECYL GALLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DODECYL GALLATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DODECYL GALLATE carries the following function designation(s):

ANTIOXIDANT

CAS 1166-52-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DODECYL GALLATE

This page reproduces the CosIng inventory entry for DODECYL GALLATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DODECYL GALLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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