Is DISODIUM EDTA safe to use in EU cosmetics?

DISODIUM EDTA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains DISODIUM EDTA?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3360415/11/2016

DISODIUM EDTA

Disodium dihydrogen ethylenediaminetetraacetate

DISODIUM EDTA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6381-92-6

CAS 6381-92-6PubChem CID 44120005

Edta disodium

IUPAC name: disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;dihydrate

Molecular formula: C10H18N2Na2O10
Molecular weight: 372.24 g/mol
Exact mass: 372.07568334 Da
Topological polar surface area: 163.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 12
Covalent units: 5
Defined stereocentres: 0

Also known as

EDTA disodium saltDisodium dihydrogen ethylenediaminetetraacetate dihydrateethylenediaminetetraacetic acid disodium dihydrateDisodium edetate dihydrate; Disodium ethylenediaminetetraacetate dihydratedisodium edetate (edta)139-33-3Ethylenediaminetetraacetic acid disodium salt, dihydrateEthylenediaminetetraacetic acid, disodium salt dihydrate, ACS reagent

12 more reported names

Ceftriaxone Impurity 39disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate;dihydrateEDTA disodium salt, dihydrateC10H18N2Na2O10139-33-3(Anhydrate CAS)EBC-252156BP-20565DA-62921DISODIUM 2-({2-[BIS(CARBOXYMETHYL)AMINO]ETHYL}(CARBOXYLATOMETHYL)AMINO)ACETATE DIHYDRATEEthylenediaminetetraaceticaciddisodiumsaltdihydrateaceticacid,(ethylenedinitrilo)tetra-,disodiumsalt,dihydrateEthylenediaminetetraacetic Acid Disodium Salt Dihydrogen(Discontinued,See C4X-116339)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

PubMed:5160

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DISODIUM EDTA

INCI name

DISODIUM EDTA

INN name

edetate disodium

Ph. Eur. name

natrii edetas

Description

Disodium dihydrogen ethylenediaminetetraacetate

Record provenance

Inventory reference: 33604
Imported identity: DISODIUM EDTA
Source update: 15/11/2016

European Commission CosIng source notes

Annex records for DISODIUM EDTA

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Key data

CAS

139-33-3 --- 6381-92-6

205-358-3

Restriction

—

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9345 · DISODIUM EDTA

Ingredients with overlapping formulation functions

DIPOTASSIUM OXALATEANTICORROSIVE, CHELATING

DIPROPYL OXALATECHELATING, PLASTICISER, SOLVENT

DISODIUM ALUMINATE GLUCARATE/GLUCONATE/GLYCOLATE/TARTRATE/OXALATECHELATING

DISODIUM AZACYCLOHEPTANE DIPHOSPHONATECHELATING

DISODIUM EDTA-COPPERASTRINGENT, CHELATING

DISODIUM ETIDRONATECHELATING

DISODIUM GLUCARATE/GLUCONATE/GLUCURONATE/GLYCOLATE/KETOGLUCONATE/OXALATE/TARTRA…CHELATING

DISODIUM HYDROXYETHYLAMINO BISMETHYLPHOSPHONATECHELATING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DISODIUM EDTA appears in the CosIng inventory

The CosIng inventory lists DISODIUM EDTA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DISODIUM EDTA is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DISODIUM EDTA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DISODIUM EDTA carries the following function designation(s):

CAS 139-33-3 --- 6381-92-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for DISODIUM EDTA

This page reproduces the CosIng inventory entry for DISODIUM EDTA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DISODIUM EDTA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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