Is CITRULLINE safe to use in EU cosmetics?

CITRULLINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 372-75-8?

CAS 372-75-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CITRULLINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3286315/10/2010

CITRULLINE

L-Ornithine, N(5)-(aminocarbonyl)-

CITRULLINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 372-75-8

CAS 372-75-8PubChem CID 9750

Citrulline

L-citrulline is the L-enantiomer of citrulline. It has a role as a micronutrient, a protective agent, a nutraceutical, an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is an enantiomer of a D-citrulline. It is a tautomer of a L-citrulline zwitterion. — ChEBI

IUPAC name: (2S)-2-amino-5-(carbamoylamino)pentanoic acid

Molecular formula: C6H13N3O3
Molecular weight: 175.19 g/mol
Exact mass: 175.09569129 Da
XLogP3: -4.3
Topological polar surface area: 118.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 1

Also known as

L-citrullinedelta-UreidonorvalineSitrullineN5-Carbamoyl-L-ornithine(S)-2-Amino-5-ureidopentanoic acidL-CytrullineN5-(Aminocarbonyl)-L-ornithineCitrulline, L-

16 more reported names

N(delta)-CarbamylornithineN5-(Aminocarbonyl)ornithineL-2-Amino-5-ureidovaleric acidN5-carbamoylornithinealpha-Amino-delta-ureidovaleric acidL-Ornithine, N5-(aminocarbonyl)-2-Amino-5-ureidovaleric acid29VT07BGDA2-Amino-5-uredovaleric acidNgamma-carbamylornithineN(5)-(aminocarbonyl)-L-ornithineNSC-27425CHEBI:16349CHEBI:18211alpha-amino-gamma-ureidovaleric acidRefChem:5693

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16349
ChEMBL:CHEMBL444814
EPA DTXSID:DTXSID80883373
PubMed:38770826
PubMed:37778480
PubMed:23122508
PubMed:23111298
PubMed:23109853
PubMed:23107525
PubMed:23075591
PubMed:23075551
PubMed:23074829
PubMed:23067347
PubMed:23062354
PubMed:23060885

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CITRULLINE

INCI name

CITRULLINE

Description

L-Ornithine, N(5)-(aminocarbonyl)-

Record provenance

Inventory reference: 32863
Imported identity: CITRULLINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CITRULLINE

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Key data

CAS

372-75-8

206-759-6

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6627 · CITRULLINE

Ingredients with overlapping formulation functions

CITRINESKIN CONDITIONING

CITRINE EXTRACTSKIN CONDITIONING

CITROBACTER/SOY PROTEIN FERMENTSKIN CONDITIONING

CITROFORTUNELLA MICROCARPA FRUIT EXTRACTANTIOXIDANT, SKIN CONDITIONING

CITRULLUS COLOCYNTHIS FRUIT EXTRACTSKIN CONDITIONING

CITRULLUS LANATUS FRUIT EXTRACTSKIN CONDITIONING

CITRULLUS LANATUS FRUIT WATERSKIN CONDITIONING

CITRULLUS LANATUS SEED EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CITRULLINE appears in the CosIng inventory

The CosIng inventory lists CITRULLINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CITRULLINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CITRULLINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CITRULLINE carries the following function designation(s):

SKIN CONDITIONING

CAS 372-75-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CITRULLINE

This page reproduces the CosIng inventory entry for CITRULLINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CITRULLINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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