Is CHAMAZULENE safe to use in EU cosmetics?

CHAMAZULENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 529-05-5?

CAS 529-05-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CHAMAZULENE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3263115/10/2010

CHAMAZULENE

7-Ethyl-1,4-dimethylazulene

CHAMAZULENE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 529-05-5

CAS 529-05-5PubChem CID 10719

Chamazulene

Chamazulene is a sesquiterpenoid. — ChEBI

IUPAC name: 7-ethyl-1,4-dimethylazulene

Molecular formula: C14H16
Molecular weight: 184.28 g/mol
Exact mass: 184.125200510 Da
XLogP3: 4.4
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

ChamazulenDimethuleneCamazuleneDimethulen1,4-Dimethyl-7-ethylazuleneAzulene, 7-ethyl-1,4-dimethyl-7-ethyl-1,4-dimethyl-azuleneZ439UH6E5F

16 more reported names

BA-2784RefChem:32250208-449-6BA 2784AZULENE, 1,4-DIMETHYL-7-ETHYL-EINECS 208-449-6BRN 1306577dimethyleneUNII-Z439UH6E5FDimethwlenLindazuleneCHAMAZULENE [MI]CHAMAZULENE [WHO-DD]4-05-00-01736 (Beilstein Handbook Reference)CHEBI:35731,4-Dimethyl-7-ethyl-Azulene

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3573
ChEMBL:CHEMBL495665
EPA DTXSID:DTXSID70200939
PubMed:22682202
PubMed:22428258
PubMed:22410959
PubMed:22397992
PubMed:22096322
PubMed:21922427
PubMed:21912695
PubMed:21188586
PubMed:21152302
PubMed:20420329
PubMed:20385420
PubMed:20013472

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CHAMAZULENE

INCI name

CHAMAZULENE

Description

7-Ethyl-1,4-dimethylazulene

Record provenance

Inventory reference: 32631
Imported identity: CHAMAZULENE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CHAMAZULENE

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Key data

CAS

529-05-5

208-449-6

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#6070 · CHAMAZULENE

Ingredients with overlapping formulation functions

CHAMAECYPARIS OBTUSA BRANCH/LEAF EXTRACTHUMECTANT, SKIN CONDITIONING

CHAMAECYPARIS OBTUSA LEAF EXTRACTSKIN CONDITIONING

CHAMAECYPARIS OBTUSA LEAF OILSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

CHAMAECYPARIS OBTUSA LEAF/ROOT EXTRACTSKIN CONDITIONING

CHAMOMILLA RECUTITA (MATRICARIA) FLOWER JUICESKIN CONDITIONING

CHAMOMILLA RECUTITA EXTRACTSKIN CONDITIONING

CHAMOMILLA RECUTITA FLOWERSKIN CONDITIONING

CHAMOMILLA RECUTITA FLOWER EXTRACTFRAGRANCE, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CHAMAZULENE appears in the CosIng inventory

The CosIng inventory lists CHAMAZULENE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CHAMAZULENE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CHAMAZULENE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CHAMAZULENE carries the following function designation(s):

SKIN CONDITIONING

CAS 529-05-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CHAMAZULENE

This page reproduces the CosIng inventory entry for CHAMAZULENE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CHAMAZULENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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