What function does CETETHYL MORPHOLINIUM ETHOSULFATE serve in cosmetics?

According to the EU CosIng inventory, CETETHYL MORPHOLINIUM ETHOSULFATE carries the following function designation(s): ANTIMICROBIAL, ANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING.

What other records share CAS 78-21-7?

CAS 78-21-7 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3257815/10/2010

CETETHYL MORPHOLINIUM ETHOSULFATE

4-Ethyl-4-hexadecylmorpholinium ethyl sulphate

CETETHYL MORPHOLINIUM ETHOSULFATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 78-21-7

CAS 78-21-7PubChem CID 60971

Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1)

The CIR Expert Panel concludes that the available data are insufficient to support the safety of Cetethyl Morpholinium Ethosulfate for use in cosmetic products. — Cosmetic Ingredient Review (CIR)

IUPAC name: 4-ethyl-4-hexadecylmorpholin-4-ium;ethyl sulfate

Molecular formula: C24H51NO5S
Molecular weight: 465.7 g/mol
Exact mass: 465.34879490 Da
Topological polar surface area: 84.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 2
Defined stereocentres: 0

Also known as

Quaternium-25Atlas G 263Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfateCetethyl morpholinium ethosulfateN-Cetyl-N-ethylmorpholinium ethyl sulfateG 251G 263G-263

16 more reported names

4-Ethyl-4-hexadecylmorpholinium ethyl sulfate4-Ethyl-4-hexadecyl morpholinium ethyl sulfateCetyl ethyl morpholinium ethosulfateFU19SYM476BARQUAT CMENSC-215231Sulfuric acid, monoethyl ester, ion(1-), 4-ethyl-4-hexadecylmorpholiniumG-251RefChem:124690201-094-8Barquat cme-ACETYLETHYLMORPHOLINIUM ETHOSULFATEN-Cetyl-N-ethylmorpholinium ethosulfateN-Cetyl-N-ethylmorpholinium ethylsulfateEthyl-N-hexadecylmorpholinium ethosulfateN-Hexadecyl-N-ethylmorpholinium ethyl sulfate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID4051245

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CETETHYL MORPHOLINIUM ETHOSULFATE

INCI name

CETETHYL MORPHOLINIUM ETHOSULFATE

Description

4-Ethyl-4-hexadecylmorpholinium ethyl sulphate

Record provenance

Inventory reference: 32578
Imported identity: CETETHYL MORPHOLINIUM ETHOSULFATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CETETHYL MORPHOLINIUM ETHOSULFATE

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Key data

CAS

78-21-7

201-094-8

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
ANTISTATIC: Preventing and/or reducing static electricity by neutralising electrical charge on surfaces.
HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.
SURFACTANT - CLEANSING: Wetting body surfaces, emulsifying or solubilizing oils, and suspending soil (generally, such ingredients contribute to the foaming and lathering properties of cleansing products).
SURFACTANT - EMULSIFYING: Helping suspensions or dispersions of liquids in a second liquid by reducing the surface tension of the substances to be emulsified.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#5931 · CETETHYL MORPHOLINIUM ETHOSULFATE

Ingredients with overlapping formulation functions

CENTELLA ASIATICA OILANTIMICROBIAL, ANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

CERASTIUM ARCTICUM CALLUS CULTURE EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

CETALKONIUM CHLORIDEANTIMICROBIAL, ANTISTATIC, PRESERVATIVE

CETEARALKONIUM BROMIDEANTIMICROBIAL, ANTISTATIC, PRESERVATIVE

CETETHYLDIMONIUM BROMIDEANTIMICROBIAL, ANTISTATIC, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

CETRIMONIUM BROMIDEANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT - EMULSIFYING

CETRIMONIUM CHLORIDEANTIMICROBIAL, ANTISTATIC, PRESERVATIVE, SURFACTANT - EMULSIFYING

CETRIMONIUM METHOSULFATEANTIMICROBIAL, ANTISTATIC, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CETETHYL MORPHOLINIUM ETHOSULFATE appears in the CosIng inventory

The CosIng inventory lists CETETHYL MORPHOLINIUM ETHOSULFATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CETETHYL MORPHOLINIUM ETHOSULFATE is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CETETHYL MORPHOLINIUM ETHOSULFATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CETETHYL MORPHOLINIUM ETHOSULFATE carries the following function designation(s):

CAS 78-21-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CETETHYL MORPHOLINIUM ETHOSULFATE

This page reproduces the CosIng inventory entry for CETETHYL MORPHOLINIUM ETHOSULFATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CETETHYL MORPHOLINIUM ETHOSULFATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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