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Official EU label nameGlossary entry 9204

DIPHENYL ETHER

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:101-84-8
EC:202-981-2
Ingredient index records:
DIPHENYL ETHER
Cosmetic functions: FRAGRANCE

Benzene, 1,1'-Oxybis

Open full local profile
1 matched or reported name
DIPHENYL ETHER

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

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MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Chemical identity and properties

PubChem 2D chemical structure for CAS 101-84-8
CAS 101-84-8PubChem CID 7583

Diphenyl Ether

IUPAC name
phenoxybenzene
Molecular formula
C12H10O
Molecular weight
170.21 g/mol
Exact mass
170.073164938 Da
XLogP3
4.2
Topological polar surface area
9.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Diphenyl oxidePhenyl etherBenzene, 1,1'-oxybis-DiphenyletherOxybisbenzenePhenyl oxideBiphenyl oxideGeranium crystals
16 more reported names
OxydiphenylChemcryl JK-EBBenzene, phenoxy-1,1'-Oxybis(benzene)1,1'-OxybisbenzeneEther, diphenylFEMA No. 36673O695R5M1UNSC-19311CHEBI:39258phenoxy benzenePhenyl ether (vapor)RefChem:5768202-981-2Oxydibenzene1,1'-oxydibenzene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:39258

diphenyl ether

An aromatic ether in which the oxygen is attached to two phenyl substituents. It has been found in muscat grapes and vanilla.

Formula
C12H10O
Average mass
170.211 g/mol
Monoisotopic mass
170.07316 Da
Formal charge
0
  • aromatic ether — is a (CHEBI:35618)
  • plant metabolite — has role (CHEBI:76924)
  • plant metabolite — has role (CHEBI:76924)
  • aromatic ether — is a (CHEBI:35618)
Additional curated names
1,1'-oxydibenzenephenoxybenzene1,1'-oxybis(benzene)1,1'-oxybisbenzeneDiphenylaetherdiphenyl etherDiphenyletherDiphenyloxiddiphenyl oxideoxybisbenzenephenyl ether
Cross-references from this source
  • CAS: 101-84-8 — NIST Chemistry WebBook
  • CAS: 101-84-8 — ChemIDplus
  • REGISTRY_NUMBER: 1364620 — Reaxys
  • REGISTRY_NUMBER: 165477 — Gmelin
  • MANUAL_X_REF: Diphenyl_ether — Wikipedia
  • MANUAL_X_REF: HMDB0034446 — HMDB

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-06-21. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7583

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Note: This chemical does not meet GHS hazard criteria for 0.5% (12 of 2199) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (84.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H400 (16.1%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (10.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (78.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P273, P280, P305+P351+P338, P337+P317, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2199 reports by companies from 45 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 12 of 2199 reports by companies.; There are 44 notifications provided by 2187 of 2199 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation] Source: NITE-CMC
  • Toxicity Summary: IDENTIFICATION AND USE: Diphenyl ether exists as a colorless crystalline solid or liquid with a unpleasant odor. It is insoluble in water and soluble in ether, benzene and acetic acid. The odor is extremely unpleasant. It is used in large quantities in soap perfumes and its main application is as a heat transfer medium (eutectic mixture with diphenyl) and as a chemical intermediate for reactions such as halogenation, acylation, alkylation; it is also used as a dye carrier. Employed as a processing aid in the production of polyesters. HUMAN EXPOSURE AND TOXICITY: Contact with a commercial product containing diphenyl ether has caused burning of the eyes, irritation of the respiratory tract, and severe nausea along with skin irritation. Oral exposure to a commercial product containing this chemical has caused severe degenerative changes in the liver and kidney. Prolonged exposure of skin to liquid causes reddening and irritation. Occupational exposure to diphenyl ether occurs through dermal contact and inhalation of vapor. Its use in various soap, detergent, creams, lotion, and perfume formulations results in general population exposure through inhalation and dermal contact. Diphenyl Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Using a 4-day exposure period, a diphenyl ether steady-state BCF of 195 was measured in rainbow trout (Salmo gairdneri)(1). A steady-state BCF of 470 has also been reported for rainbow trout after 7 day exposure period at 16 ug/L(2). Using a 4-day exposure period a BCF of 590 was measured in rainbow trout(3). BCF ranges of 112-583 and 49-594 were calculated using carp (Cyprinus carpio) which were exposed to 0.3 and 0.03 ppm, respectively, over an 8-week period(4). According to a classification scheme(5), these data suggest that bioconcentration in aquatic organisms is moderate to high(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 1950(2), indicates that diphenyl ether is expected to have low mobility in soil(SRC). Volatilization of diphenyl ether from moist soil surfaces may be an important fate process(SRC) given its Henry's Law constant estimated as 2.8X10-4 atm-cu m/mole(SRC) based upon its vapor pressure, 2.25X10-2 mm Hg(3), and water solubility, 18 mg/L(4). Diphenyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 2.25X10-2 mm Hg at 25 °C(3). A 6.3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 1950(2), indicates that diphenyl ether is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces may be expected(3) based upon an estimated Henry's Law constant of 2.8X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 2.25X10-2 mm Hg(4), and water solubility, 18 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 6 days, respectively(SRC). According to a classification scheme(6), experimental BCF values of 195, 470 and 590, suggest that bioconcentration in aquatic organisms is moderate to high(SRC). A 6.3% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diphenyl ether, which has a vapor pressure of 2.25X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diphenyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3 days(SRC), calculated from its rate constant of 9.8X10-12 cu cm/molecule-sec at 25 °C(3). Diphenyl ether contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Intermediate; Fragrance; Heat transferring agent; Processing aids not otherwise specified; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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