Official EU label nameGlossary entry 6448

CI 75120

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 3 of 13 indexed market datasets: 3 country records and 1 EU Annex records. Every result and evidence gap is listed below.

3 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:1393-63-1542-40-56983-79-5

EC:215-735-4208-810-8230-248-7289-561-2

Ingredient index records:

CI 75120

Cosmetic functions: COLORANT

Annatto; 6,6'-Diapo-psi.,psi.-carotenedioic acid

Inventory restriction note: IV/109

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3 matched or reported names

CI 75120Annatto2E,4E,6E,8E,10E,12E,14E,16Z,18E)-4,8,13,17-Tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid (Natural Orange 4, annatto)

Regulatory evidence in all 13 markets

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	Conditional positive-list match	1Open record 1	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	Review every linked record and exact conditions.
Great Britain GB	Permitted list with conditions	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Permitted list with conditions	2Open record 1 Open record 2	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	No local match	0	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China CN	No local match	0	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	No local match	0	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	No local match	0	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India IN	No local match	0	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia SA	No local match	0	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Matching market records and conditions

European Union

Regulation (EC) 1223/2009 consolidated to 1 May 2026

CI 75120Annex IV

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

AnnattoPermitted list with conditions

Purity criteria as set out in Commission Directive 95/45/EC (E 160b)

GB Cosmetics Regulation, Annex IV, entry 109 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

2E,4E,6E,8E,10E,12E,14E,16Z,18E)-4,8,13,17-Tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid (Natural Orange 4, annatto)Permitted list with conditions

Colour index: 75120 · CAS: 1393-63-1 · Colour: Orange · Other limitations: E 160b

Schedule 6, reference 109, source row 111 · effective-2026-01-01

2E,4E,6E,8E,10E,12E,14E,16Z,18E)-4,8,13,17-Tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid (Natural Orange 4, annatto)Permitted list with conditions

Colour index: 75120 · CAS: 6983-79-5 · Colour: Orange · Other limitations: E 160b

Schedule 6, reference 109, source row 113 · effective-2026-01-01

Exact Annex II–VI evidence

Annex IVentry 109

Open full regulatory record

CI 75120

Warnings: Purity criteria as set out in Commission Directive 95/45/EC (E 160b)

Chemical identity and properties

PubChem 2D chemical structure for CAS 542-40-5

CAS 542-40-5PubChem CID 5281249

Norbixin

Norbixin is a diterpenoid. — ChEBI

IUPAC name: (2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid

Molecular formula: C24H28O4
Molecular weight: 380.5 g/mol
Exact mass: 380.19875937 Da
XLogP3: 7.2
Topological polar surface area: 74.6 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

E8M59E17AIbeta-norbixinRefChem:927893208-810-8trans-norbixinNorbixin (>70%)6,6'-Diapo-psi,psi-carotenedioic acidEINECS 208-810-8

14 more reported names

9'-cis-Diapo-omega,omega-carotinsaeureUNII-E8M59E17AI9'-cis-6,6'-Diapocaroten-6,6'-disaeureall-trans-Norbixin(2E,4Z,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-TETRAMETHYLICOSA-2,4,6,8,10,12,14,16,18-NONAENEDIOIC ACID.BETA.-NORBIXINALL-TRANS NORBIXINNORBIXIN [MART.].BETA.-NORBIXIN [MI]CHEBI:7623MSK5908TN83552,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-(ALL-E)-4,8,13,17-TETRAMETHYL-2,4,6,8,10,12,14,16,18-EICOSANONAENEDIOIC ACID

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:7623
ChEMBL:CHEMBL1602127
EPA DTXSID:DTXSID20274024

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6983-79-5

CAS 6983-79-5PubChem CID 5281226

Bixin

Bixin is a carotenoic acid that is the 6'-monomethyl ester of 9'-cis-6,6'-diapocarotene-6,6'-dioic acid. It has a role as an antioxidant, a biological pigment, an insulin-sensitizing drug, an anti-inflammatory agent, an apoptosis inducer and a food colouring. It is a methyl ester, a carotenoic acid and a dicarboxylic acid monoester. — ChEBI

IUPAC name: (2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid

Molecular formula: C25H30O4
Molecular weight: 394.5 g/mol
Exact mass: 394.21440943 Da
XLogP3: 7.5
Topological polar surface area: 63.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Methyl (9-cis)-hydrogen-6,6'-diapo-psi,psi-carotenedioate9L7T4VB66GAnnatto (E 160b)E160bCHEBI:31362,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid, 4,8,13,17-tetramethyl-, monomethyl ester, (2E,4Z,6E,8E,10E,12E,14E,16E,18E)-RefChem:29838230-248-7

16 more reported names

cis-Bixin20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acidIsobixinStable bixin6'-methyl hydrogen 9'-Z-6,6'-diapocarotene-6,6'-dioate6'-methyl hydrogen 9'-cis-6,6'-diapocarotene-6,6'-dioateC25H30O4alpha-BixinEINECS 230-248-7UNII-9L7T4VB66GCCRIS 9384a-Bixin(9-cis)-6,6'-diapo-?,?-carotenedioic acid 6-methyl ester; a-Bixin; BixinolBIXINS CIS-FORM.ALPHA.-BIXINBIXIN [MART.]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3136
ChEMBL:CHEMBL1172615
EPA DTXSID:DTXSID1024629
PubMed:30698894

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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