Official EU label nameGlossary entry 3221

BENZOPHENONE-3

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 5 of 13 indexed market datasets: 4 country records and 1 EU Annex records. Every result and evidence gap is listed below.

5 markets with evidence
Markets checked
13
Markets with evidence
5
Evidence gaps
8
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:131-57-7
EC:205-031-5
Ingredient index records:
BENZOPHENONE-3
Cosmetic functions: LIGHT STABILIZER, UV ABSORBER, UV FILTER

2-Hydroxy-4-methoxybenzophenone

Inventory restriction note: VI/4

7 matched or reported names
BENZOPHENONE-3oxybenzone2-Hydroxy-4-methoxybenzophenone / OxybenzoneBenzophenone-32-Hydroxy-4-methoxy-benzophenone (benzophenone-3, oxybenzone)2-Hydroxy-4-methoxy-benzophenone/Oxybenzone Benzophenone-3 CAS No. 131-57-7벤조페논-3(옥시벤존)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Swipe or scroll horizontally to see dataset coverage and next actions.

MarketResultRecordsDatasetMeaning / next action
European Union
EU
Conditional positive-list match1Open record 1
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
Review every linked record and exact conditions.
Great Britain
GB
Permitted list with conditions1Open record 1
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
Review every linked record and exact conditions.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
Permitted list with conditions1Open record 1
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
Review every linked record and exact conditions.
ASEAN
ASEAN
Permitted list with conditions1Open record 1
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Review every linked record and exact conditions.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
Restricted1Open record 1
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Review every linked record and exact conditions.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Matching market records and conditions

Exact Annex II–VI evidence

BENZOPHENONE-3

Product scope: a) Face products, hand products, and lip products, excluding propellant and pump spray products b) Body products, including propellant and pump spray products c) Other products

Maximum concentration: a) 6% b) 2,2% c) 0,5% Footnote 1: However, cosmetic products containing '2-Hydroxy-4-methoxy-benzophenone/Oxybenzone' and complying with the restrictions set out in Regulation (EC) No 1223/2009 as applicable on 27 July 2022 may be placed on the Union market until 28 January 2023 and be made available on the Union market until 28 July 2023.

Restrictions: a) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 5,5 %. b) If used at 0,5 % to protect product formulation, the levels used as UV filter must not exceed 1,7 %.

Warnings: For a) and b): Contains Benzophenone-3 (*) Footnote (*): Not required if concentration is 0,5 % or less and when it is used only for product protection purposes.

Chemical identity and properties

PubChem 2D chemical structure for CAS 131-57-7
CAS 131-57-7PubChem CID 4632

2-Hydroxy-4-methoxybenzophenone

IUPAC name
(2-hydroxy-4-methoxyphenyl)-phenylmethanone
Molecular formula
C14H12O3
Molecular weight
228.24 g/mol
Exact mass
228.078644241 Da
XLogP3
3.6
Topological polar surface area
46.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

oxybenzoneBenzophenone-32-Benzoyl-5-methoxyphenolAdvastab 45Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-OxybenzonAnuvex4-Methoxy-2-hydroxybenzophenone
16 more reported names
Ongrostab HMBOxibenzonaUsaf cy-9Spectra-sorb UV 9Chimassorb 90OxybenzonumUvinul 9Syntase 62Uvistat 24Cyasorb UV 9Sunscreen UV-15Uvinul M40Escalol 567NSC-7778Oxibenzonum(2-Hydroxy-4-methoxyphenyl)phenylmethanone
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match4632

Attributed physical-property, hazard, environmental and use annotations.

  • Boiling Point: 302 to 320 °F at 5 mmHg (NTP, 1992) Source: CAMEO Chemicals
  • Boiling Point: 155 °C at 5.00E+00 mm Hg Source: DrugBank
  • Substance: 2-Hydroxy-4-methoxybenzophenone Source: NTP Technical Reports
  • NTP Technical Report: TR-597: Toxicology and Carcinogenesis Studies of 2-Hydroxy-4- methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (2020 ) Source: NTP Technical Reports
  • Peer Review Date: 12/12/19 Source: NTP Technical Reports
  • Conclusion for Male Rat: Equivocal Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
  • Summary: Under the conditions of these 2-year studies, there was equivocal evidence of carcinogenic activity of 2H4MBP exposure in male Hsd:Sprague Dawley SD rats based on the occurrence of malignant meningiomas in the brain. There was equivocal evidence of carcinogenic activity in female Hsd:Sprague Dawley SD rats based on the increased incidence of thyroid C-cell adenomas and the increased incidence of uterine stromal polyps. There was no evidence of carcinogenic activity in male or female B6C3F1/N mice at exposure concentrations of 1,000, 3,000, and 10,000 ppm.; Increases in the incidences of nonneoplastic lesions of the testis in male rats and of the uterus and adrenal cortex in female rats occurred with exposure to 2H4MBP. Increases in the incidences of nonneoplastic lesions of the bone marrow (males and females), spleen (males and females), kidney (males and females), and liver (males) in mice occurred with exposure to 2H4MBP. Source: NTP Technical Reports
  • Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 6% (116 of 1945) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (70.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (70.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (69.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (14.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (24.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1945 reports by companies from 26 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 116 of 1945 reports by companies.; There are 24 notifications provided by 1829 of 1945 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3; BP-3) forms crystals or powder. It is used as an ultraviolet light absorber and stabilizer, especially in plastics and paints. It is also used as a broad-band UV filter in concentrations of up to 10% in sunscreen products alone or in combination with other UV filters. It serves not only to prevent sunburn but also to protect against the photodynamic, photosensitizing, and phototoxic effects of various drugs. HUMAN STUDIES: Photosensitivity to the UV-blocking agent benzophenone-3 has been reported. ANIMAL STUDIES: Benzophenone-3 was not a skin sensitizer in mice. Mice received benzophenone-3 in concentrations of 0; 3,125; 6,250; 12,500; 25,000 and 50,000 ppm in the diet for 13 weeks. The following effects were noted: 554 mg/kg bw/day: no adverse effects noted. 1,246 mg/kg bw/day: increased liver weight. 2,860 mg/kg bw/day: increased liver weight. 6,780 mg/kg bw/day: decreased body weight gain in males and females; increased liver weight; minimal cytoplasmic vacuolisation of hepatocytes. 16,238 mg/kg bw/day: decreased body weight gain in males and females; minimal renal lesions in males; increased liver weight; Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of 39-160 and 33-156 were reported in fish for 2-hydroxy-4-methoxybenzophenone, using carp (Cyprinus carpio) which were exposed over an 10-week period at respective concentrations of 0.1 and 0.01 mg/L(1). According to a classification scheme(2), this BCF range suggests the bioconcentration in aquatic organisms is moderate to high. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Bioaccumulation and trophic transfer in ecosystems is an important criterion for assessing environmental risks of contaminants. This study investigated bioaccumulation and biomagnification of 13 organic ultraviolet absorbents (UVAs) in marine wildlife organisms in the Pearl River Estuary, South China Sea. The UVAs could accumulate in the organisms with biota - sediment accumulation factors (BSAF) of 0.003-2.152. UV531 was the most abundant and showed the highest tendency to accumulate in the organisms with a median BSAF of 1.105. The UVAs demonstrated species - and compound-specific accumulation in the marine organism. Fishes showed significantly higher capability than the cephalopods and crustaceans in accumulation of the UVAs. Habitat did not demonstrate obvious impact on accumulation of the UVA. On the other hand, benzophenone-3, UV328, and UV234 showed significantly higher concentration in the detritus feeding fishes than carnivorous and planktivorous fishes, suggesting governing effect of dietary habits of the organisms on bioaccumulation of these UVAs. Direct uptake from growth media was a significant exposure pathway of the organisms to the UVAs. The estimated trophic magnif Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 950(SRC), determined from a structure estimation method(2), indicates that 2-hydroxy-4-methoxybenzophenone is expected to have low mobility in soil(SRC). The estimated pKa of 2-hydroxy-4-methoxybenzophenone is 7.1(3), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the anion from moist soil is not expected because anions do not volatilize(SRC). Volatilization of neutral 2-hydroxy-4-methoxybenzophenone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(5). 2-Hydroxy-4-methoxybenzophenone is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). A 4% of Theoretical BOD using activated sludge in the Japanese MITI test suggests that 2-hydroxy-4-methoxybenzophenone is no Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 950(SRC), determined from a structure estimation method(2), indicates that 2-hydroxy-4-methoxybenzophenone is expected to adsorb to suspended solids and sediment(SRC). An estimated pKa of 7.1(3) indicates 2-hydroxy-4-methoxybenzophenone will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces of the anion is not expected to be an important fate process(SRC). Volatilization from water surfaces of neutral 2-hydroxy-4-methoxybenzophenone is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). 2-Hydroxy-4-methoxybenzophenone did not undergo hydrolysis or volatilization in sterile controls incubated at 25 °C for 42 days(6). According to a classification scheme(7), BCFs of 33-160, reported for 2-hydroxy-4-methoxybenzophenone in carp (Cyprinus carpio), exposed over an 10-week period(8), suggest bioconcentration in aquatic organisms is moderate to high. 2-Hydroxy-4-methoxybenzophenone may biodegrade, based on half-lives of 10.7 and 4.2-8.7 days under aerobic and Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hydroxy-4-methoxybenzophenone, which has an estimated vapor pressure of 6.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-hydroxy-4-methoxybenzophenone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.9 hours(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase 2-hydroxy-4-methoxybenzophenone may be removed from the air by wet and dry deposition(SRC). 2-Hydroxy-4-methoxybenzophenone absorbs light at maximum of 287 nm with absorption extending to 400 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity

US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity

Continue the compliance check

1. Confirm identity

Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.

2. Review restrictions

Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.

3. Verify the formula

Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.

Screen in a formulaOpen standalone comparison

Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision