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Official EU label nameGlossary entry 17484

NITROUS OXIDE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:10024-97-2
EC:233-032-0
Ingredient index records:
NITROUS OXIDE
Ph. Eur. name: nitrogenii oxidum
Cosmetic functions: PROPELLANT

Dinitrogen oxide

Open full local profile
3 matched or reported names
NITROUS OXIDEnitrous oxidenitrogenii oxidum

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

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MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Chemical identity and properties

PubChem 2D chemical structure for CAS 10024-97-2
CAS 10024-97-2PubChem CID 948

Nitrous Oxide

IUPAC name
nitrous oxide
Molecular formula
N2O
Molecular weight
44.013 g/mol
Exact mass
44.001062628 Da
XLogP3
0.5
Topological polar surface area
19.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Laughing gasDinitrogen oxideDinitrogen monoxideFactitious airnitrogen protoxideNitrogen oxide (N2O)Hyponitrous acid anhydrideNitrogen hypoxide
16 more reported names
Stickdioxydoxyde nitreuxOxido nitrosoGas, Laughingprotoxyde d'azoteNitrous oxide, compressedOxide, NitrousDistickstoffmonoxidFEMA No. 2779Nitrogenum oxygenatumProtoxide of nitrogenDinitrogenii oxidumNitrogen oxide (n(sub 2)o)INS NO.942INS-942K50XQU1029
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:17045

dinitrogen oxide

A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Formula
N2O
Average mass
44.013 g/mol
Monoisotopic mass
44.00106 Da
Formal charge
0
  • gas molecular entity — is a (CHEBI:138675)
  • nitrogen oxide — is a (CHEBI:35196)
  • NMDA receptor antagonist — has role (CHEBI:60643)
  • inhalation anaesthetic — has role (CHEBI:38870)
  • bacterial metabolite — has role (CHEBI:76969)
  • general anaesthetic — has role (CHEBI:38869)
  • vasodilator agent — has role (CHEBI:35620)
  • analgesic — has role (CHEBI:35480)
  • food packaging gas — has role (CHEBI:77974)
  • refrigerant — has role (CHEBI:78433)
  • greenhouse gas — has role (CHEBI:76413)
  • raising agent — has role (CHEBI:77971)
  • food propellant — has role (CHEBI:78017)
  • NMDA receptor antagonist — has role (CHEBI:60643)
  • inhalation anaesthetic — has role (CHEBI:38870)
  • bacterial metabolite — has role (CHEBI:76969)
  • general anaesthetic — has role (CHEBI:38869)
  • vasodilator agent — has role (CHEBI:35620)
  • analgesic — has role (CHEBI:35480)
  • food packaging gas — has role (CHEBI:77974)
  • refrigerant — has role (CHEBI:78433)
  • greenhouse gas — has role (CHEBI:76413)
  • raising agent — has role (CHEBI:77971)
  • food propellant — has role (CHEBI:78017)
  • gas molecular entity — is a (CHEBI:138675)
  • nitrogen oxide — is a (CHEBI:35196)
Additional curated names
dinitrogen oxideoxidodinitrogen(N--N)diazyne 1-oxideDinitrogen monoxideDinitrogen oxideDistickstoffmonoxidE942factitious airgaz hilarantLachgaslaughing gasnitrogenium oxydulatumnitrogen protoxideNitrous oxideNNON2Ooxyde nitreuxprotoxyde d'azoteR-744AStickstoff(I)-oxid
Cross-references from this source
  • CAS: 10024-97-2 — KEGG COMPOUND
  • CAS: 10024-97-2 — ChemIDplus
  • CAS: 10024-97-2 — NIST Chemistry WebBook
  • REGISTRY_NUMBER: 2153410 — Gmelin
  • REGISTRY_NUMBER: 8137358 — Reaxys
  • MANUAL_X_REF: 4238 — DrugCentral
  • MANUAL_X_REF: C00887 — KEGG COMPOUND
  • MANUAL_X_REF: c0650 — UM-BBD
  • MANUAL_X_REF: D00102 — KEGG DRUG
  • MANUAL_X_REF: N2O — PDBeChem
  • MANUAL_X_REF: Nitrous_oxide — Wikipedia

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-10-13. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match948

Attributed physical-property, hazard, environmental and use annotations.

  • Physical Description: Nitrous oxide is a colorless, sweet-tasting gas. It is also known as "laughing gas". Continued breathing of the vapors may impair the decision making process. It is noncombustible but it will accelerate the burning of combustible material in a fire. It is soluble in water. Its vapors are heavier than air. Exposure of the container to prolonged heat or fire can cause it to rupture violently and rocket. It is used as an anesthetic, in pressure packaging, and to manufacture other chemicals. Source: CAMEO Chemicals
  • Physical Description: Nitrous oxide, refrigerated liquid appears as a colorless liquid. Density 1.22 g / cm3 at its boiling point of -89 °C. Boils to give a colorless gas that is sweet-smelling and moderately toxic. The gas has narcotic effects when inhaled (laughing gas). Shipped under refrigeration. Vapor pressure is at about 745 psig at 70 °F. Used to freeze foods and to manufacture other chemicals. Source: CAMEO Chemicals
  • Physical Description: CBI; Gas Vapor Source: EPA Chemical Data Reporting (CDR)
  • Physical Description: Colourless, non-flammable gas, sweetish odour Source: EU Food Improvement Agents
  • Physical Description: Colorless gas with a slightly sweet odor. [inhalation anesthetic] [Note: Shipped as a liquefied compressed gas.] [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Physical Description: Liquid Source: Human Metabolome Database (HMDB)
  • Physical Description: COLOURLESS COMPRESSED LIQUEFIED GAS WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
  • Physical Description: Colorless gas with a slightly sweet odor. Source: Occupational Safety and Health Administration (OSHA)
  • Physical Description: Colorless gas with a slightly sweet odor. [inhalation anesthetic] [Note: Shipped as a liquefied compressed gas.] Source: The National Institute for Occupational Safety and Health (NIOSH)
  • First Aid: Excerpt from NIOSH Pocket Guide for Nitrous oxide:; Eye: FROSTBITE - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.; Skin: FROSTBITE - If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water.; Breathing: FRESH AIR - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary. (NIOSH, 2024) Source: CAMEO Chemicals
  • ERG2024, Guide 122 (Nitrous oxide, compressed; Nitrous oxide, refrigerated liquid; Nitrous oxide): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • ERG2024, Guide 122 (Nitrous oxide; Nitrous oxide, compressed; Nitrous oxide, refrigerated liquid): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Frostbite - If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible.; Skin: Frostbite - Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.; Breathing: Fresh air Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H270 (100%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H280 (56.4%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H281 (40.6%): Contains refrigerated gas; may cause cryogenic burns or injury [Warning Gases under pressure]; H336 (31.7%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P220, P244, P261, P271, P282, P304+P340, P319, P336+P317, P370+P376, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 663 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P220, P244, P260, P261, P264, P270, P271, P280, P304+P340, P318, P319, P370+P376, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P220, P244, P260, P261, P264, P270, P271, P280, P304+P340, P318, P319, P370+P376, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P220, P244, P370+P376, P403, and P410+P403 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Nitrous Oxide is a stable, non-irritating colorless gas with slightly sweetish odor and taste. It is used as anesthetic in dentistry and surgery, propellant gas in food aerosols, leak detection. HUMAN EXPOSURE AND TOXICITY: The main complication following inhalation of nitrous oxide is varying degrees of hypoxia, affecting the functions of the heart and the brain. This may be associated with hypotension, fatal cardiac arrhythmias, headache, dizziness, anoxic brain damage, cerebral edema and permanent mental deficit. Chronic exposure can cause neurological and hematological changes including megaloblastic erythropoiesis and neurological features similar to subacute combined degeneration of the spinal cord. Nitrous oxide should not be administered for more than 24 hours because of the risk of bone marrow depression. During induction with high concentrations of nitrous oxide, the oxygen in the lungs is rapidly used up and the anoxia with increased respiratory effort causes rapid depletion of carbon dioxide in the issues. Absence of carbon dioxide and depression of the medullary centers by the anesthetic quickly lead to respiratory failure, and rarely, the patie Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: While nitrous oxide inactivates methionine synthase, intraoperative use results in a transient metabolic abnormality that soon reverses upon replacing the degrading enzyme.; When nitrous oxide is used recurrently (during occupational exposure or as a drug of abuse), it may lead to megaloblastic anemia with neurologic dysfunction. This situation also may occur in patients with an unrecognized cobalamin deficiency (vegans, pernicious anemia, hereditary disorders of cobalamin, and folate metabolism). Subacute combined degeneration of the spinal cord (SACD) and death is reported with repeated exposure in a case of a rare congenital 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency. Source: StatPearls
  • Environmental Fate: ATMOSPHERIC FATE: Nitrous oxide has an atmospheric lifetime of 114 years. The Global Warming Potential = 298 (100-year)(1). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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