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CAS 97-53-0

CAS 97-53-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 97-53-0
CAS 97-53-0PubChem CID 3314

Eugenol

Eugenol is a phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis. It has a role as a sensitiser, a volatile oil component, an antibacterial agent, an analgesic, an antineoplastic agent, a flavouring agent, an EC 1.4.3.4 (monoamine oxidase) inhibitor, a voltage-gated sodium channel blocker, an anaesthetic, a radical scavenger, an allergen, an anti-inflammatory agent, an apoptosis inducer, a NF-kappaB inhibitor and a human blood serum metabolite. It is an alkenylbenzene, a monomethoxybenzene, a phenylpropanoid and a member of phenols. It is functionally related to a guaiacol. — ChEBI

IUPAC name
2-methoxy-4-prop-2-enylphenol
Molecular formula
C10H12O2
Molecular weight
164.20 g/mol
Exact mass
164.083729621 Da
XLogP3
2.0
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

4-Allyl-2-methoxyphenol4-AllylguaiacolEugenic acidAllylguaiacolCaryophyllic acidp-Eugenolp-AllylguaiacolEngenol
16 more reported names
2-Methoxy-4-allylphenolPhenol, 2-methoxy-4-(2-propenyl)-5-Allylguaiacol2-Methoxy-4-(2-propenyl)phenolSynthetic eugenol1,3,4-Eugenol4-Allylcatechol-2-methyl ether1-Hydroxy-2-methoxy-4-allylbenzene2-methoxy-4-(prop-2-en-1-yl)phenol2-Methoxy-1-hydroxy-4-allylbenzene4-Allyl-1-hydroxy-2-methoxybenzenebioxedaPhenol, 4-allyl-2-methoxy-FEMA No. 24674-Allylcatechol 2-methyl ether4-Hydroxy-3-methoxyallylbenzene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 97-53-0

1 total
Annex
III
Entry
71

Eugenol

Phenol, 2-methoxy-4-(2-propenyl)-

The presence of the substance must be indicated in the list of ingredients referred to in Article 19(1)g when its concentration exceeds: - 0.001% in leave-on products - 0.01% in rinse-off products

EC
202-589-1

How CAS 97-53-0 is used on this site

CAS 97-53-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 97-53-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 97-53-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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