Why does CAS 94-24-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 94-24-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 94-24-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 94-24-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 94-24-6

Q: How do I use CAS 94-24-6 for compliance screening?

Cross-reference CAS 94-24-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 94-24-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 94-24-6

CAS 94-24-6PubChem CID 5411

Tetracaine

Tetracaine is a benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia. It has a role as a local anaesthetic. It is a benzoate ester and a tertiary amino compound. — ChEBI

IUPAC name: 2-(dimethylamino)ethyl 4-(butylamino)benzoate

Molecular formula: C15H24N2O2
Molecular weight: 264.36 g/mol
Exact mass: 264.183778013 Da
XLogP3: 3.7
Topological polar surface area: 41.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

AmethocaineLaudocaineMetrasprayPontocaineAnetainDicaineUromucaesthinContralgin

16 more reported names

FissucainIntercainMedicaineMeethobalmMucaesthinNiphanoidMedihaler-TetracaineTetracainaTetrakainDicainDikainTetracainum2-(Dimethylamino)ethyl p-(butylamino)benzoatep-Butylaminobenzoyl-2-dimethylaminoethanolBenzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl esterDiaethylaminoaethanol ester der p-butylaminobenzoesaeure

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:9468
ChEMBL:CHEMBL698
EPA DTXSID:DTXSID1043883
PubMed:23118524
PubMed:23115719
PubMed:23061994
PubMed:22963754
PubMed:22946020
PubMed:22943969
PubMed:22915870
PubMed:22855901
PubMed:22842001
PubMed:22831890
PubMed:22791966
PubMed:22753757

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 94-24-6

1 total

Annex

Entry

Tetracaine (INN) and its salts

202-316-6

How CAS 94-24-6 is used on this site

CAS 94-24-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 94-24-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 94-24-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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