Why does CAS 91-80-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 91-80-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 91-80-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 91-80-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 91-80-5

Q: How do I use CAS 91-80-5 for compliance screening?

Cross-reference CAS 91-80-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 91-80-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 91-80-5

CAS 91-80-5PubChem CID 4098

Methapyrilene

Methapyrilene is a member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group. It has a role as a sedative, a H1-receptor antagonist, an anti-allergic agent and a carcinogenic agent. — ChEBI

IUPAC name: N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-2-ylmethyl)ethane-1,2-diamine

Molecular formula: C14H19N3S
Molecular weight: 261.39 g/mol
Exact mass: 261.12996879 Da
XLogP3: 2.6
Topological polar surface area: 47.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

ThenylpyraminePyrinistolThionylanRestrylMetapyrileneSleepwellSemikonParadormalene

16 more reported names

LullaminPyrathynPyrinistabThenyleneTenalinRest-onHistadrylLulaminmethypyrileneMetapirilenoPyrahistineHistaseThenylene baseTenalin baseMetapirileneMethapyrilenum

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:6820
ChEMBL:CHEMBL1411979
EPA DTXSID:DTXSID2023278
PubMed:35690182
PubMed:31555880
PubMed:30467583
PubMed:30157460
PubMed:28935588
PubMed:28903497
PubMed:28552552
PubMed:28529062
PubMed:28108177
PubMed:28013212
PubMed:27358234
PubMed:26946349

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 91-80-5

1 total

Annex

Entry

144

Methapyrilene (INN) and its salts

202-099-8

How CAS 91-80-5 is used on this site

CAS 91-80-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 91-80-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 91-80-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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