Why does CAS 89-25-8 appear in more than one EU cosmetic annex?

A substance identified by CAS 89-25-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 89-25-8?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 89-25-8 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 89-25-8

Q: How do I use CAS 89-25-8 for compliance screening?

Cross-reference CAS 89-25-8 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 89-25-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 89-25-8

CAS 89-25-8PubChem CID 4021

Mci-186

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as an antioxidant and a radical scavenger. — ChEBI

IUPAC name: 5-methyl-2-phenyl-4H-pyrazol-3-one

Molecular formula: C10H10N2O
Molecular weight: 174.20 g/mol
Exact mass: 174.079312947 Da
XLogP3: 1.3
Topological polar surface area: 32.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

MCI 186RefChem:57584edaravone3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONERadicutNorphenazone1-Phenyl-3-methyl-5-pyrazoloneDeveloper Z

16 more reported names

MethylphenylpyrazoloneNorantipyrineC.I. Developer 1PhenylmethylpyrazolonePhenyl methyl pyrazoloneRadicava3-Methyl-1-phenyl-5-pyrazolone3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one3-Methyl-1-phenyl-2-pyrazoline-5-one1-Phenyl-3-methyl-5-oxo-2-pyrazoline3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-1-Phenyl-3-methylpyrazolone2-Pyrazolin-5-one, 3-methyl-1-phenyl-1-Phenyl-3-methylpyrazolone-52,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31530
ChEMBL:CHEMBL290916
EPA DTXSID:DTXSID9021130
PubMed:39431643
PubMed:39326406
PubMed:36343683
PubMed:34309930
PubMed:33663100
PubMed:32135237
PubMed:31364409
PubMed:31344373
PubMed:30810406
PubMed:30758894
PubMed:30240821
PubMed:29937981

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 89-25-8

1 total

Annex

III

Entry

228

PHENYL METHYL PYRAZOLONE

3-Methyl-1-phenyl-5-pyrazolone

To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black he…

201-891-0

How CAS 89-25-8 is used on this site

CAS 89-25-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 89-25-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 89-25-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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