Why does CAS 86-13-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 86-13-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 86-13-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 86-13-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 86-13-5

Q: How do I use CAS 86-13-5 for compliance screening?

Cross-reference CAS 86-13-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 86-13-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 86-13-5

CAS 86-13-5PubChem CID 1201549

med.21724, Compound Benztropine

Benzatropine is tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments. It has a role as a oneirogen, an antiparkinson drug, a muscarinic antagonist, a parasympatholytic and an antidyskinesia agent. — ChEBI

IUPAC name: (1R,5S)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane

Molecular formula: C21H25NO
Molecular weight: 307.4 g/mol
Exact mass: 307.193614421 Da
XLogP3: 4.5
Topological polar surface area: 12.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 2

Also known as

RefChem:1088905benztropineBenzatropineCobrentinTropine benzohydryl etherBenzatropinaBenzatropinumBenztropinum

16 more reported names

CogentineAkitan3endo-benzhydryloxytropaneBenzatropinum [INN-Latin]Benzatropina [INN-Spanish]Cogentinol3alpha-(diphenylmethoxy)tropaneHSDB 3014NK 021NHL2J4X8KApo Benztropine3alpha-(Diphenylmethoxy)-1alphaH,5alphaH-tropaneNK-02Benzatropine (INN)Benzatropine [INN]Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3048
ChEBI:CHEBI:94707
ChEMBL:CHEMBL1201203
ChEMBL:CHEMBL1618180
ChEMBL:CHEMBL438151
EPA DTXSID:DTXSID9022659
PubMed:34326460
PubMed:28176326
PubMed:25973388
PubMed:25548026
PubMed:24709263
PubMed:20142494
PubMed:17897630
PubMed:16134091
PubMed:12966155
PubMed:11978145
PubMed:10952768
PubMed:7562926

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 86-13-5

1 total

Annex

Entry

158

Benzatropine (INN) and its salts

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How CAS 86-13-5 is used on this site

CAS 86-13-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 86-13-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 86-13-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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