Why does CAS 823-40-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 823-40-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 823-40-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 823-40-5 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 823-40-5

Q: How do I use CAS 823-40-5 for compliance screening?

Cross-reference CAS 823-40-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 823-40-5 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 823-40-5

CAS 823-40-5PubChem CID 13205

2,6-Diaminotoluene

2,6-diaminotoluene is a diamine that is toluene in which both of the hydrogens ortho- to the methyl group are replaced by amino groups. It has a role as a mutagen. It is a diamine and a primary amino compound. It derives from a hydride of a toluene. — ChEBI

IUPAC name: 2-methylbenzene-1,3-diamine

Molecular formula: C7H10N2
Molecular weight: 122.17 g/mol
Exact mass: 122.084398327 Da
XLogP3: 0.9
Topological polar surface area: 52.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

2,6-ToluenediamineToluene-2,6-diamine1,3-Benzenediamine, 2-methyl-2-Methyl-m-phenylenediamine2-Methyl-1,3-benzenediamine2,6-Tolylenediamine2,6-Toluylenediamine2,6-Diamino-1-methylbenzene

16 more reported names

2-Methyl-1,3-phenylenediamineo-Toluene diamineToluene, 2,6-diamino-1,3-DIAMINO-2-METHYLBENZENERODOL 26DATNSC-147490H838Q10551CHEBI:762882,6-DATRefChem:83124212-513-9EINECS 212-513-9NSC 147490CCRIS 3031HSDB 4131Tolylene-2,6-diamine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:76288
ChEMBL:CHEMBL1489438
EPA DTXSID:DTXSID4027319
PubMed:23077796
PubMed:22319232
PubMed:22084566
PubMed:22016709
PubMed:21447151
PubMed:20869512
PubMed:20656055
PubMed:20026473
PubMed:18606566
PubMed:17728315
PubMed:17267016
PubMed:17070881

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 823-40-5

2 total

Annex

Entry

413

2-Methyl-m-phenylenediamine (Toluene-2,6-diamine)

212-513-9

CMR

How CAS 823-40-5 is used on this site

CAS 823-40-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 823-40-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 823-40-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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