Why does CAS 80-77-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 80-77-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 80-77-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 80-77-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 80-77-3

Q: How do I use CAS 80-77-3 for compliance screening?

Cross-reference CAS 80-77-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 80-77-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 80-77-3

CAS 80-77-3PubChem CID 2717

Chlormezanone

Chlormezanone is a 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions. It has a role as an anxiolytic drug, an antipsychotic agent and a muscle relaxant. It is a lactam, a sulfone, a 1,3-thiazine and a member of monochlorobenzenes. — ChEBI

IUPAC name: 2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one

Molecular formula: C11H12ClNO3S
Molecular weight: 273.74 g/mol
Exact mass: 273.0226421 Da
XLogP3: 1.1
Topological polar surface area: 62.8 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

ChlormethazanoneTrancopalChlormethazoneChlormezanonClormetazanoneClormetazonPhenaroldl-Chlormezanone

16 more reported names

BanabinClorilaxMiorilaxRilansylRilaquilRilassolSupotranTanafolBisinaRexanRilaxBanabin-sintyalMio-sedBanabil-sintyalChlormezanonumClormezanona

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3619
ChEMBL:CHEMBL1200714
EPA DTXSID:DTXSID3022798
PubMed:33814510
PubMed:28108177
PubMed:22804998
PubMed:22666603
PubMed:21286431
PubMed:21162721
PubMed:20839897
PubMed:19852273
PubMed:19830193
PubMed:16762044
PubMed:16703253
PubMed:15897685

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 80-77-3

1 total

Annex

Entry

Chlormezanone (INN)

201-307-4

How CAS 80-77-3 is used on this site

CAS 80-77-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 80-77-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 80-77-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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