Why does CAS 80-09-1 appear in more than one EU cosmetic annex?

A substance identified by CAS 80-09-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 80-09-1?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 80-09-1 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 80-09-1

Q: How do I use CAS 80-09-1 for compliance screening?

Cross-reference CAS 80-09-1 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 80-09-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 80-09-1

CAS 80-09-1PubChem CID 6626

Bisphenol S

4,4'-sulfonyldiphenol is a sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups. It has a role as an endocrine disruptor and a metabolite. It is a bisphenol and a sulfone. It is functionally related to a diphenyl sulfone. — ChEBI

IUPAC name: 4-(4-hydroxyphenyl)sulfonylphenol

Molecular formula: C12H10O4S
Molecular weight: 250.27 g/mol
Exact mass: 250.02997997 Da
XLogP3: 1.9
Topological polar surface area: 83.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

4,4'-SulfonyldiphenolBis(4-hydroxyphenyl) sulfonePhenol, 4,4'-sulfonylbis-4,4'-Dihydroxydiphenyl sulfoneBis(p-hydroxyphenyl) sulfoneDiphone CBis(4-hydroxyphenyl)sulfone1,1'-Sulfonylbis(4-hydroxybenzene)

16 more reported names

BPS 14,4'-Sulphonyldiphenol3OX4RR782RNSC-8712NSC-683541CHEBI:343721,1'-Sulfonylbis[4-hydroxybenzene]RefChem:569577201-250-54,4-Sulfonyldiphenol4,4'-Sulfonylbisphenol4-Hydroxyphenyl sulfone4,4'-Bisphenol SSulphonylbisphenolBis(p-hydroxyphenyl)sulfoneP,P'-Dihydroxydiphenyl sulfone

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:34372
ChEMBL:CHEMBL384441
EPA DTXSID:DTXSID3022409
PubMed:42114668
PubMed:40721063
PubMed:40669749
PubMed:40531193
PubMed:40513842
PubMed:40203079
PubMed:40086502
PubMed:39933604
PubMed:39929295
PubMed:39793866
PubMed:39577800
PubMed:39298647

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 80-09-1

1 total

Annex

Entry

1702

4,4’-sulphonyldiphenol; bisphenol S

201-250-5

How CAS 80-09-1 is used on this site

CAS 80-09-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 80-09-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 80-09-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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