Why does CAS 78-11-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 78-11-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 78-11-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 78-11-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 78-11-5

Q: How do I use CAS 78-11-5 for compliance screening?

Cross-reference CAS 78-11-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 78-11-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 78-11-5

CAS 78-11-5PubChem CID 6518

Pentaerythritol Tetranitrate

Pentaerythritol tetranitrate is a pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex. It has a role as a vasodilator agent and an explosive. — ChEBI

IUPAC name: [3-nitrooxy-2,2-bis(nitrooxymethyl)propyl] nitrate

Molecular formula: C5H8N4O12
Molecular weight: 316.14 g/mol
Exact mass: 316.01387170 Da
XLogP3: 1.4
Topological polar surface area: 220.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 12
Covalent units: 1
Defined stereocentres: 0

Also known as

PETNPenthriteNitropentaPeritrateNitropentaerythritePentaerithrityl tetranitrateNitropentaerythritolPenthrit

16 more reported names

VasodiatolBaritrateNitropentonPentafinPentanitrinePentanitrolPentritolQuintrateAngicapAntoraCorpentErinitPeritylPeridex-LAPentritol tempulesDipentrate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:25879
ChEMBL:CHEMBL466659
EPA DTXSID:DTXSID2023430
PubMed:26351025
PubMed:23611293
PubMed:23049947
PubMed:22978386
PubMed:22950443
PubMed:22934993
PubMed:22761430
PubMed:22704330
PubMed:22647196
PubMed:22645602
PubMed:22614581
PubMed:22606302

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 78-11-5

1 total

Annex

Entry

265

Pentaerithrityl tetranitrate (INN)

201-084-3

How CAS 78-11-5 is used on this site

CAS 78-11-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 78-11-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 78-11-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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