Why does CAS 74070-46-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 74070-46-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 74070-46-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 74070-46-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 74070-46-5

Q: How do I use CAS 74070-46-5 for compliance screening?

Cross-reference CAS 74070-46-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 74070-46-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 74070-46-5

CAS 74070-46-5PubChem CID 92389

Aclonifen

Aclonifen is a primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops. It has a role as a carotenoid biosynthesis inhibitor, a herbicide, an agrochemical and an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor. It is an aromatic ether, a C-nitro compound, a substituted aniline, a primary amino compound and a member of monochlorobenzenes. — ChEBI

IUPAC name: 2-chloro-6-nitro-3-phenoxyaniline

Molecular formula: C12H9ClN2O3
Molecular weight: 264.66 g/mol
Exact mass: 264.0301698 Da
XLogP3: 3.8
Topological polar surface area: 81.1 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

BandurChallenge2-Chloro-6-nitro-3-phenoxybenzenamineCME 1271762RDA835CHEBI:137374CME-127RefChem:109279

16 more reported names

277-704-1Benzenamine, 2-chloro-6-nitro-3-phenoxy-AclonifeneA1L38Aclonifen [BSI:ISO]2-chloro-6-nitro-3-phenoxy-anilineEINECS 277-704-1UNII-1762RDA8352-Chloro-3-phenoxy-6-nitroanilineACLONIFEN [ISO]ACLONIFEN [MI]2-Chloro-3-phenoxy-6-nitro-anilineAclonifen 10 microg/mL in AcetonitrileAclonifen 100 microg/mL in AcetonitrileAS-83168A3211

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:137374
ChEMBL:CHEMBL1485557
EPA DTXSID:DTXSID7058175
PubMed:28927721
PubMed:20369492
PubMed:19382587
PubMed:17390816
PubMed:17390814
PubMed:17313105
PubMed:12558095

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 74070-46-5

1 total

Annex

Entry

1566

Aclonifen (ISO); 2-chloro-6-nitro-3-phenoxyaniline

277-704-1

CMR

How CAS 74070-46-5 is used on this site

CAS 74070-46-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 74070-46-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 74070-46-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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