Why does CAS 688046-61-9 appear in more than one EU cosmetic annex?

A substance identified by CAS 688046-61-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 688046-61-9 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 688046-61-9

Q: How do I use CAS 688046-61-9 for compliance screening?

Cross-reference CAS 688046-61-9 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 688046-61-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 688046-61-9

CAS 688046-61-9PubChem CID 23082663

Pyriofenone

Pyriofenone is an aromatic ketone that is metrafenone in which the 3-bromo-6-methoxy-2-methylphenyl group is replaced by a 5-chloro-2-methoxy-4-methylpyridin-3-yl group. It is a fungicide developed for the control of powdery mildew in cereals and grape vines. It has a role as an antifungal agrochemical. It is an aromatic ether, a chloropyridine, an aromatic ketone and an aryl phenyl ketone fungicide. — ChEBI

IUPAC name: (5-chloro-2-methoxy-4-methyl-3-pyridinyl)-(2,3,4-trimethoxy-6-methylphenyl)methanone

Molecular formula: C18H20ClNO5
Molecular weight: 365.8 g/mol
Exact mass: 365.1030004 Da
XLogP3: 3.8
Topological polar surface area: 66.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

Pyriofenone [ISO]IKF-309UNII-4ER76S8IFJ4ER76S8IFJ(5-chloro-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone(5-chloro-2-methoxy-4-methyl-3-pyridinyl)(2,3,4-trimethoxy-6-methylphenyl)methanoneCHEBI:83346(5-chloro-2-methoxy-4-methyl-3-pyridyl)(4,5,6-trimethoxy-o-tolyl)methanone

10 more reported names

RefChem:177777692-456-8(5-chloro-2-methoxy-4-methylpyridin-3-yl)-(2,3,4-trimethoxy-6-methylphenyl)methanoneIKF 3093-(2,3,4-Trimethoxy-6-methylbenzoyl)-5-chloro-2-methoxy-4-methylpyridineC18H20ClNO5Pyriofenone 100 microg/mL in AcetonitrileDB-214953(5-chloro-2-methoxy-4-methyl-3-pyridyl)-(2,3,4-trimethoxy-6-methyl-phenyl)methanoneMethanone, (5-chloro-2-methoxy-4-methyl-3-pyridinyl)(2,3,4-trimethoxy-6-methylphenyl)-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:83346
EPA DTXSID:DTXSID8058162

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 688046-61-9

1 total

Annex

Entry

1683

(5-chloro-2-methoxy-4-methyl-3-pyridyl)(4,5,6-trimethoxy-o-tolyl)methanone; pyriofenone

692-456-8

CMR

How CAS 688046-61-9 is used on this site

CAS 688046-61-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 688046-61-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 688046-61-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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