Why does CAS 680-31-9 appear in more than one EU cosmetic annex?

A substance identified by CAS 680-31-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 680-31-9?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 680-31-9 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 680-31-9

Q: How do I use CAS 680-31-9 for compliance screening?

Cross-reference CAS 680-31-9 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 680-31-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 680-31-9

CAS 680-31-9PubChem CID 12679

Hexamethylphosphoramide

Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant. — ChEBI

IUPAC name: N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine

Molecular formula: C6H18N3OP
Molecular weight: 179.20 g/mol
Exact mass: 179.11874920 Da
XLogP3: 0.3
Topological polar surface area: 26.8 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

HMPAHexamethylphosphoric triamideHexametapolHempaHMPTAHexamethylphosphoric acid triamidePhosphoric hexamethyltriamideHexamethylphosphorotriamide

16 more reported names

Eastman Inhibitor HPTPhosphoric triamide, hexamethyl-HexamethylphosphotriamideTris(dimethylamino)phosphine oxideHexamethylorthophosphoric triamidePhosphoric acid hexamethyltriamidePhosphoric tris(dimethylamide)Phosphoryl hexamethyltriamideHexamethyl phosphoramideN,N,N',N',N'',N''-hexamethylphosphoric triamideHexamethylfosforamidTris(dimethylamino)phosphorus oxideENT 50882HexamethylphosphamideENT 50,882hexamethylphosphoramide triamide

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:24565
ChEMBL:CHEMBL3187047
EPA DTXSID:DTXSID6020694
PubMed:22799197
PubMed:22590350
PubMed:22492203
PubMed:22412807
PubMed:22199530
PubMed:22169867
PubMed:22099703
PubMed:22091163
PubMed:22065643
PubMed:22065241
PubMed:22064929
PubMed:21852847

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 680-31-9

1 total

Annex

Entry

748

Hexamethylphosphoric-triamide

211-653-8

CMR

How CAS 680-31-9 is used on this site

CAS 680-31-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 680-31-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 680-31-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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