Why does CAS 68-12-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 68-12-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 68-12-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 68-12-2 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 68-12-2

Q: How do I use CAS 68-12-2 for compliance screening?

Cross-reference CAS 68-12-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 68-12-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 68-12-2

CAS 68-12-2PubChem CID 6228

Dimethylformamide

N,N-dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. It has a role as a geroprotector, a polar aprotic solvent and a hepatotoxic agent. It is a volatile organic compound and a member of formamides. It is functionally related to a formamide. — ChEBI

IUPAC name: N,N-dimethylformamide

Molecular formula: C3H7NO
Molecular weight: 73.09 g/mol
Exact mass: 73.052763847 Da
XLogP3: -1.0
Topological polar surface area: 20.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

Dimethyl formamideN-FormyldimethylamineFormamide, N,N-dimethyl-DimethylformamidDMFAN,N-Dimethyl formamideFormyldimethylamineDimetilformamide

16 more reported names

DwumetyloformamidDimetylformamiduDMF (amide)NCI-C60913N,N DimethylformamideDimethylamid kyseliny mravenciN,N-DimetilformamidaU-4224NSC 5356NSC-5356Formic acid, amide, N,N-dimethyl-EPA Pesticide Chemical Code 366200NSC53568696NH0Y2XCHEBI:17741RefChem:6468

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17741
ChEMBL:CHEMBL268291
EPA DTXSID:DTXSID6020515
PubMed:41765525
PubMed:37995826
PubMed:35238128
PubMed:31875996
PubMed:31501917
PubMed:29984871
PubMed:28505332
PubMed:26795242
PubMed:26387567
PubMed:25380136
PubMed:23449067
PubMed:23125608

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 68-12-2

1 total

Annex

Entry

355

Dimethylformamide (N,N-Dimethylformamide)

200-679-5

CMR

How CAS 68-12-2 is used on this site

CAS 68-12-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 68-12-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 68-12-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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