Why does CAS 65-49-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 65-49-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 65-49-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 65-49-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 65-49-6

Q: How do I use CAS 65-49-6 for compliance screening?

Cross-reference CAS 65-49-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 65-49-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 65-49-6

CAS 65-49-6PubChem CID 4649

4-Aminosalicylic Acid

4-aminosalicylic acid is an aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. It has a role as an antitubercular agent. It is an aminobenzoic acid and a member of phenols. It is functionally related to a salicylic acid. It is a conjugate acid of a 4-aminosalicylate(1-). — ChEBI

IUPAC name: 4-amino-2-hydroxybenzoic acid

Molecular formula: C7H7NO3
Molecular weight: 153.14 g/mol
Exact mass: 153.042593085 Da
XLogP3: 1.3
Topological polar surface area: 83.6 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Aminosalicylic acidP-AMINOSALICYLIC ACIDParamycinParasalPaserParasalindonDeapasilApacil

16 more reported names

GabbropasParasalicilAminoparEntepasPamacylPasalonPasnodiaPasolacPropasaOsacylPasaraPasemPasmedPasaPara-PasSanipirol-4

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:27565
ChEMBL:CHEMBL1169
EPA DTXSID:DTXSID2022591
PubMed:26277036
PubMed:24333643
PubMed:24290060
PubMed:23779105
PubMed:23118010
PubMed:23114617
PubMed:23112434
PubMed:22967331
PubMed:22915310
PubMed:22881439
PubMed:22872445
PubMed:22830224

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 65-49-6

1 total

Annex

Entry

4-Aminosalicylic acid and its salts

200-613-5

How CAS 65-49-6 is used on this site

CAS 65-49-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 65-49-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 65-49-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 65-49-6 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 65-49-6 in your documentation.