Why does CAS 6441-77-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 6441-77-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 6441-77-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 6441-77-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 6441-77-6

Q: How do I use CAS 6441-77-6 for compliance screening?

Cross-reference CAS 6441-77-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 6441-77-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6441-77-6

CAS 6441-77-6PubChem CID 22948

Phloxine

IUPAC name: dipotassium;2',4',5',7'-tetrabromo-4,7-dichloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate

Molecular formula: C20H4Br4Cl2K2O5
Molecular weight: 793.0 g/mol
Exact mass: 791.54024 Da
Topological polar surface area: 81.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 5
Covalent units: 3
Defined stereocentres: 0

Also known as

Acid red 98C.I. ACID RED 98CI acid red 98C.I. 45405QDW0T759T6CI 45405Dipotassium 3,6-dichloro-2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoateFluorescein, 4,7-dichloro-2',4',5',7'-tetrabromo-, dipotassium salt

16 more reported names

Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',3',5',7'-tetrabromo-4,7-dichloro-3',6'-dihydroxy-, dipotassium saltSpiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-4,7-dichloro-3',6'-dihydroxy-, potassium salt (1:2)Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-4,7-dichloro-3',6'-dihydroxy-, potassium salt (1:2)RefChem:1731992',4',5',7'-Tetrabromo-4,7-tetrabromo-4,7-dichloro-3',6'-dihydrox-yspiro(isobenzofuran-1(3H)9'-(9H)xanthen)-3-one, dipotassium salt229-225-4Phloxine KToyo Acid PhloxineCCRIS 9133JBBPTUVOZCXCSU-UHFFFAOYSA-LEINECS 229-225-4PhloxineDISCONTINUEDUNII-QDW0T759T6C.I. FOOD RED 922,4,5,7-Tetrabromo-12,15-dichlorofluorescein, dipotassium salt4,6-Dichloro-2',4',5',7'-tetrabromofluorescein dipotassium salt

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID80912314
PubMed:20041016
PubMed:18310892
PubMed:537126

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 6441-77-6

1 total

Annex

Entry

CI 45405

Dipotassium 3,6-dichloro-2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate

Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

229-225-4

Max concentration

How CAS 6441-77-6 is used on this site

CAS 6441-77-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 6441-77-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 6441-77-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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