Why does CAS 6440-58-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 6440-58-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 6440-58-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 6440-58-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 6440-58-0

Q: How do I use CAS 6440-58-0 for compliance screening?

Cross-reference CAS 6440-58-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 6440-58-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 6440-58-0

CAS 6440-58-0PubChem CID 22947

DMDM hydantoin

1,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin) is an antimicrobial formaldehyde releaser preservative with the trade name Glydant. DMDM hydantoin is an organic compound belonging a class of compounds known as hydantoins. It is used in the cosmetics industry and found in products like shampoos, hair conditioners and skin care products. (L1896) — Toxin and Toxin Target Database (T3DB)

IUPAC name: 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione

Molecular formula: C7H12N2O4
Molecular weight: 188.18 g/mol
Exact mass: 188.07970687 Da
XLogP3: -0.2
Topological polar surface area: 81.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

DmdmhGlydant1,3-Bis(hydroxymethyl)-5,5-dimethylhydantoin1,3-Dimethylol-5,5-dimethylhydantoinDantoin-DMDMHGlycoserve-DMDMHDantoin dmdmh 55Dimethylol-5,5-dimethylhydantoin

16 more reported names

Dmdmh 552,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-1,3-Bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedioneBYR0546TOW1,3-Di(hydroxymethyl)-5,5-dimethylhydantoin1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOINDDAC0.15%Hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl-RefChem:55057DDAC0.6%229-222-8938-621-2Dimethyloldimethyl hydantoindimethyloldimethylhydantoin1,3-DIHYDROXYMETHYL-5,5-DIMETHYLHYDANTOINDMDM HYDANTOIN [II]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID8035217
PubMed:22633837
PubMed:22034943
PubMed:21952107
PubMed:21951136
PubMed:21767276
PubMed:20731691
PubMed:20572887
PubMed:20136893
PubMed:20136876
PubMed:20136875
PubMed:19508298
PubMed:17725923

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 6440-58-0

1 total

Annex

Entry

DMDM HYDANTOIN

1,3-Bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione

229-222-8

Max concentration

How CAS 6440-58-0 is used on this site

CAS 6440-58-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 6440-58-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 6440-58-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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