Why does CAS 625-45-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 625-45-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 625-45-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 625-45-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 625-45-6

Q: How do I use CAS 625-45-6 for compliance screening?

Cross-reference CAS 625-45-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 625-45-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 625-45-6

CAS 625-45-6PubChem CID 12251

Methoxyacetic Acid

Methoxyacetic acid is a monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group. It has a role as a mutagen, an antineoplastic agent, an apoptosis inducer and a human xenobiotic metabolite. It is a monocarboxylic acid and an ether. It is functionally related to an acetic acid. It is a conjugate acid of a methoxyacetate. — ChEBI

IUPAC name: 2-methoxyacetic acid

Molecular formula: C3H6O3
Molecular weight: 90.08 g/mol
Exact mass: 90.031694049 Da
XLogP3: -0.3
Topological polar surface area: 46.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Acetic acid, methoxy-Methoxyethanoic acidAcetic acid, 2-methoxy-F11T1H7Q7WNSC-7300CHEBI:132098RefChem:157058210-894-6

16 more reported names

CH3OCH2COOHmethoxy-acetic acidCAS-625-45-62-MethoxyaceticAcidCCRIS 6518Iopromide Impurity 45NSC 7300EINECS 210-894-6BRN 0635800UNII-F11T1H7Q7WAI3-241522-methoxy acetic acid2-methoxy-acetic acid(methyloxy)acetic acidalpha-methoxyacetic acidMethoxyacetic acid, 98%

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:132098
ChEMBL:CHEMBL1697714
EPA DTXSID:DTXSID1031591
PubMed:22654808
PubMed:22606332
PubMed:22580533
PubMed:22403704
PubMed:21716673
PubMed:21621602
PubMed:21573189
PubMed:21453523
PubMed:21443799
PubMed:21238576
PubMed:21203528
PubMed:20864626

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 625-45-6

1 total

Annex

Entry

674

Methoxyacetic acid

210-894-6

CMR

How CAS 625-45-6 is used on this site

CAS 625-45-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 625-45-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 625-45-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 625-45-6 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 625-45-6 in your documentation.