Why does CAS 59820-43-8 appear in more than one EU cosmetic annex?

A substance identified by CAS 59820-43-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 59820-43-8?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 59820-43-8 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 59820-43-8

Q: How do I use CAS 59820-43-8 for compliance screening?

Cross-reference CAS 59820-43-8 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 59820-43-8 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 59820-43-8

CAS 59820-43-8PubChem CID 62158

HC Yellow 4

HC Yellow No. 4 is a C-nitro compound. — ChEBI

IUPAC name: 2-[2-(2-hydroxyethoxy)-4-nitroanilino]ethanol

Molecular formula: C10H14N2O5
Molecular weight: 242.23 g/mol
Exact mass: 242.09027155 Da
XLogP3: 0.3
Topological polar surface area: 108.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

2-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethanolN,O-Di(2-hydroxyethyl)-2-amino-5-nitrophenolHC YELLOW NO. 4Colorex HCY4Ethanol, 2-[[2-(2-hydroxyethoxy)-4-nitrophenyl]amino]-2-(3-Nitro-6-(beta-hydroxyethylamino)phenoxy)ethanol0N97D5G157Ethanol, 2-((2-(2-hydroxyethoxy)-4-nitrophenyl)amino)-

16 more reported names

2-{[2-(2-hydroxyethoxy)-4-nitrophenyl]amino}ethanolRefChem:783438428-840-7NCI-C56019COLIPA B038HC YELLOW NO. 4 [IARC]Tox21_2010142-((2-(2-Hydroxyethoxy)-4-nitrophenyl)amino)ethan-1-olCCRIS 4258UNII-0N97D5G157HC amarillo 4HC Giallo 4HC Jaune 4Rodol 2G Y42-[2-(2-hydroxyethoxy)-4-nitro-anilino]ethanolCHEBI:82474

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:82474
ChEMBL:CHEMBL1573069
EPA DTXSID:DTXSID6021458

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 59820-43-8

2 total

Annex

III

Entry

253

HC Yellow No. 4

2-[bis(2-Hydroxyethyl)amino]-5-nitrophenol

— Do not use with nitrosating agents — Maximum nitrosamine content: 50 μg/kg — Keep in nitrite-free containers

428-840-7

Max concentration

Annex

III

Entry

253

HC Yellow No 4

2-[bis(2-Hydroxyethyl)amino]-5- nitrophenol

- Do not use with nitrosating agents - Maximum nitrosamine content: 50 micrograme/Kg - Keep in nitrite-free containers

428-840-7

Max concentration

How CAS 59820-43-8 is used on this site

CAS 59820-43-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 59820-43-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 59820-43-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 59820-43-8 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 59820-43-8 in your documentation.