Why does CAS 59-33-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 59-33-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 59-33-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 59-33-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 59-33-6

Q: How do I use CAS 59-33-6 for compliance screening?

Cross-reference CAS 59-33-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 59-33-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 59-33-6

CAS 59-33-6PubChem CID 5284451

Pyrilamine Maleate

Pyrilamine maleate appears as white crystals or powder. Melting point 100-101 °C. Bitter saline taste. An antihistamine. — CAMEO Chemicals

IUPAC name: (Z)-but-2-enedioic acid;N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine

Molecular formula: C21H27N3O5
Molecular weight: 401.5 g/mol
Exact mass: 401.19507097 Da
Topological polar surface area: 103.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 8
Covalent units: 2
Defined stereocentres: 0

Also known as

Mepyramine maleateAnisopyradamineHistatexHistanMinihistDiaminide maleateParaminyl maleateAntihist

16 more reported names

PyraninylRenstaminEnrumayParamalPymafedStangen maleateAnthisan maleateStatomin maleateThylogen maleateNeoantergan maleatePyranilamine maleatePyranisamine maleatePyra maleateNeo-Antergan maleatePrefrin A2786 R.P. maleate

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1201006
EPA DTXSID:DTXSID4021216
PubMed:1326

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 59-33-6

1 total

Annex

Entry

346

2-[4-Methoxybenzyl-N-(2-pyridyl)amino]ethyldimethylamine maleate (Mepyramine maleate; pyrilamine maleate)

200-422-7

How CAS 59-33-6 is used on this site

CAS 59-33-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 59-33-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 59-33-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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